Obesity Drugs are going to break the bank? Not the whole story. (Part Two)

But that’s not the whole story!  Treating obesity, proactively avoiding end-stage terrible disease states, could save real money.  I’ve attached another analysis that suggests that paying upfront may have real benefits for the patients, and the society in general.  The attached article is dense – I’ve only attached it for the economists and healthcare nerds.

It speaks to what is at the heart of what I’ve believed is a huge problem in how determining what is covered – the cost of care does not include societal cost.  As such, we only get a snapshot of true costs.  It’s like saying I don’t want to fix my car’s steering because it’s too expensive and the car is old.  Meanwhile, the chances that an accident only hurts the driver is quite small.  If you look at the whole picture, the upfront cost is easily justified.  

The whole Ozempic/Wegovy/Moujaro/Zepbound thing is still in its infancy.  It’ll get more complicated before it’s settled.  I’ll say it is a good choice for many, but, as usual, it depends.

I always try to look at the big picture – your big picture and not focus on little stuff that ends up not that important.  

If you have any questions, please give me a call.

FROM USC Schaeffer / BY Darius Lakdawalla, Bryan Tysinger, PhuongGiang Nguyen, Alison Sexton Ward & Dana Goldman

A new USC Schaeffer Center white paper finds the value to society of Medicare coverage for new classes of weight loss drugs would equal nearly $1 trillion over ten years.

Obesity is one of the United States’ most urgent health issues—and also one of the most treatable. Yet because Medicare and most private insurers do not cover weight-loss medications and many devices, just 1% of eligible patients receive treatments.  

“Obesity is a leading risk factor for mortality in the U.S.,” says Darius Lakdawalla, director of research at the USC Schaeffer Center for Health Policy & Economics and co-author of the study. “Our modeling shows that new treatments generate substantial benefits to Medicare and its beneficiaries. Developing strategies for unlocking that value should be a priority for policymakers.” Lakdawalla is also a professor at the USC Mann School of Pharmacy & Pharmaceutical Sciences and the USC Price School of Public Policy.

Leveraging the Schaeffer Center’s Future Adult Model, an economic-demographic microsimulation model, the researchers estimated the benefits of treating Americans suffering from obesity and the cost-offsets that Medicare and society could accrue if laws were changed to allow Medicare to cover anti-obesity medications. 

Coverage for new obesity treatments could generate approximately $175 billion in cost offsets to Medicare in the first 10 years alone. By 30 years, cost offsets to Medicare would increase to $700 billion.

The positive impacts extend beyond Medicare: society could reap as much as $100 billion per year (or $1 trillion over 10 years) of social benefit in the form of reduced healthcare spending and improvements in quality of life from reduced disability and pain if all eligible Americans were treated.

Models show the ripple effects of obesity on the healthcare system

Despite safe and effective treatments, federal law currently prohibits Medicare from paying for most forms of obesity procedures and medications. Legislation has been introduced, including the bipartisan Treat and Reduce Obesity Act, that would expand Medicare Part D’s prescription benefits to include FDA-approved drugs for chronic weight management.

Researchers discovered that most of the cost savings to Medicare—more than 60%—would flow to Medicare Part A, which covers hospital, hospice, nursing facility and home care.  This could significantly help Medicare, which risks becoming insolvent by 2028.

“Because obesity is associated with many chronic conditions that significantly impact patients’ lives—and Medicare’s costs—reducing obesity rates has a ripple effect in the prevalence of other conditions,” says Alison Sexton Ward, one of the co-authors of the paper and research scientist at the USC Schaeffer Center.

The researchers find that if all Americans eligible for obesity treatments gained access, the prevalence of obesity in the Medicare population would fall by 53% after the first decade.  In addition, the researchers show that treating obesity will reduce the incidence of many related diseases, including diabetes (a 5.5% reduction in prevalence after 10 years), hypertension (1.2%) and heart disease (1.7%).

Covering obesity treatments reduces health disparities

Improving access to obesity medications could also enhance health equity, since obesity disproportionately affects Black, Hispanic and lower-income communities. More than half of the Black Medicare population has obesity and three-fourths have hypertension.

“Black and other historically marginalized communities have been disproportionately burdened by obesity,” says one of the paper’s co-authors, Bryan Tysinger, director of health policy simulation at the USC Schaeffer Center and assistant research professor at the USC Price School.

Medical breakthroughs that simplify healthcare and reduce patient effort can reduce disparities, but only if access is prioritized.

Outcomes-based pricing models would ensure access

New obesity treatments promise substantial benefits to patients if policymakers can solve the problem of how to pay for them.  The researchers point to outcomes-based valuation models, including a novel pricing approach that allows for real-world evaluation of the treatments while also encouraging broad coverage.  

“About half the decline in U.S. deaths from coronary heart disease over the past 50 years can be attributed to new drugs to lower cholesterol and blood pressure,” says one of the paper’s co-authors, Dana Goldman, co-director of the USC Schaeffer Center and dean of the USC Price School. “Now imagine if Congress had prohibited coverage for these lifesaving drugs.  Novel pricing solutions can ensure access for all patients who would benefit from these important new anti-obesity treatments.”  

Source: https://healthpolicy.usc.edu/article/medic...

Chronic UTIs are awful -- but there's hope!

Don’t know what a UTI is?  This article might not be for you, but I’ll bet someone you know cares about this subject intimately!  

UTI is short for Urinary Tract Infections.  Some people (vastly more women) get UTIs constantly, are in pain as a result, have their lifes disrupted interminably and need to take antibiotics regularly, predictably screwing up a whole bunch of other stuff in their systems.  Not good.  

This article reports a cool possible solution – a pineapple flavored sublingual (under the tongue) spray of inactivated bacteria (commonly found in UTIs) daily for 3 months.  And then…Voilà!  54% of the population tested were UTI-free for 9 years!! The entire group averaged 4.5 years without a UTI.  WOW.

Of course, we’re in America, so who knows how long it will be before we see this as a real option.  But there’s hope!!

FROM MEDSCAPE UK / ANDREW R. SCOTT

Recurrent UTI Patients Find Long-Term Ally in Oral Vaccine

Results from the first long-term follow-up study of an oral vaccine for recurrent urinary tract infections (UTIs) suggest that it “could be a gamechanger for UTI prevention,” according to consultant urologist Bob Yang, who co-led the trial.

“It’s very exciting… for us it was almost magical,” said Yang, who works with the Royal Berkshire NHS Foundation Trust. Speaking to Medscape News UK, he explained that the trial, whose results are being presented at the European Association of Urology Congress (EAU) in Paris from 5 to 8 April 2024, was built on initial impressive results he and colleagues had found in private, off-licence use with a small number of patients.

Results from the first long-term follow-up study of an oral vaccine for recurrent urinary tract infections (UTIs) suggest that it “could be a gamechanger for UTI prevention,” according to consultant urologist Bob Yang, who co-led the trial.

“It’s very exciting… for us it was almost magical,” said Yang, who works with the Royal Berkshire NHS Foundation Trust. Speaking to Medscape News UK, he explained that the trial, whose results are being presented at the European Association of Urology Congress (EAU) in Paris from 5 to 8 April 2024, was built on initial impressive results he and colleagues had found in private, off-licence use with a small number of patients.

‘Dramatic’

“The results were dramatic,” Yang said. “We had women who were coming month after month with infection after infection, despite all treatment, often with last-line antibiotics. And [after using the vaccine] they came back and said what have you done to us? We are infection-free.” 

The vaccine, called Uromune, was developed by Immunotek S.L. in Spain. It is composed of inactivated whole bacteria commonly associated with UTIs: Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, and Enterococcus Faecalis. It is administered by two sprays of a pineapple flavoured suspension under the tongue every day for 3 months.

The vaccine has been used, largely off-licence, in some countries for several years, with short-term efficacy already supported by published trials in which Yang and his colleagues participated. But they wanted to more fully investigate if an initial vaccination regime could safely and effectively give long-lasting protection for people who experience recurrent UTIs.

Long-Term Results

That led to the 9-year follow-up, which investigated safety and long-term efficacy in 89 patients (72 women and 17 men) aged 18 to 87 (average age 56) with recurrent UTIs. These patients were originally treated privately at the Urology Partnership Reading, UK. 40% of the participants also had repeat doses of the vaccine after 1 or 2 years.

Forty-eight participants (54%) remained UTI-free during the 9-year follow up period, with an average UTI-free period for the entire cohort of 4.5 years. In terms of safety, Yang said no adverse effects or other concerns were identified.

Yang explained to Medscape News UK that one key purpose of the presentation to the EAU Congress was to subject the results to some initial peer review and feedback. Formal and full publication should then follow by the end of 2024.

‘Exciting’

Jennifer Rohn, professor of renal medicine and head of the Centre for Urological Biology at University College London, who was not involved in the research, told Medscape News UK: "These results are exciting and suggest that preventing UTI may be one viable strategy in our fight against an infection that afflicts around 400 million people each year, mostly women, and which antibiotics struggle to control in up to 30% of those many cases.”

Rohn added that vaccination is a particularly attractive strategy in an era when bacterial infections are becoming increasingly resistant to antibiotics. “Although people often consider UTI to be a trivial infection, there are already about a quarter of a million UTI deaths annually associated with antibiotic resistance, and this number is expected to rise,” she said. 

While acknowledging the promise of the study, Rohn did point out that it contained a relatively small number of patients who self-reported their symptoms, so she feels that larger studies will be welcome. “Also, we have to keep in mind that it was performed on individuals with relatively simple recurrent UTIs, and further work is needed to understand whether it will be as effective in complicated or chronic UTI," she said.

Next Steps

Among ongoing efforts by various researchers to address the efficacy in more complex situations, Yang said that he has won funding to test the Uromune vaccine on spinal injury patients, who can experience more complicated UTIs. This will initially proceed as a small prospective trial, then be followed by a large randomised controlled trial.

Yang also pointed out that, although many other bacteria can cause UTIs in addition to the four most common ones specifically targeted by the vaccine, these other infections also seemed covered by the vaccine. “The reason for that is likely because a lot of these gram-negative bacteria share a common lipopolysaccharide outer layer… so you get a broad-spectrum response,” along with other non-targeted effects on the immune system, he suggested.

Meantime, however, the vaccine remains unlicensed in the UK, and Yang emphasised that it would be very difficult for GPs to use it off-licence, so the next steps will be to try to move forward towards regulatory approval in the UK.

“Once this treatment gets licensed it will be revolutionary for GPs,” Yang said. While emphasising that the approval will be a slow process, he feels that the emerging data, including these recent results, are steadily feeding in the evidence that will be required.

Source: https://www.medscape.co.uk/viewarticle/rec...

Here we go again.... EXERCISE is GOOD for you

I’ve said it before, and you can bet I’ll say it again – EXERCISE is GOOD for you.  Right – you knew that.  Again, it’s the single best thing you can do to improve your overall health and longevity, as long as you do it intelligently.  So what’s new?

 The article says “Regular Exercise Linked to Better Sleep”.  Cool – but what are the details (that’s where the devil is, after all)?  

Thousands of people in 9 countries over 10 years have 30-50% better sleep when people who did exercise more than 30 minutes twice a week were compared to those who were inactive (which was 37% of the population tested!).

As usual, there’s loads of limitations to this report – two questionnaires 10 years apart and drawing conclusions from that.  But it does support that getting up and moving actually is important and has real health benefits.

GET UP!  MOVE!  

Talk soon.

Regular Exercise Linked to Better Sleep

TOPLINE:

Over time, exercising at least twice a week is associated with significantly fewer insomnia symptoms and better sleep duration, new research shows.

METHODOLOGY:

  • The study included 4339 adults aged 39-67 years (48% men) from 21 centers in nine countries participating in the third follow-up to the European Community Respiratory Health Survey (ECRHS III).

  • Participants responded to questions about physical activity, insomnia symptoms, sleep duration, and daytime sleepiness at 10-year follow-up.

  • Being "physically active" was defined as exercising with a frequency of at least twice a week for ≥ 1 hour per week.

  • The main outcome measures were insomnia, sleep time, and daytime sleepiness in relation to physical activity.

TAKEAWAY:

  • From baseline to follow-up, 37% of participants were persistently inactive, 25% were persistently active, 20% became inactive, and 18% became active.

  • After adjusting for age, sex, body mass index, smoking history, and study center, persistently active participants were less likely to report difficulties with sleep initiation (adjusted odds ratio [aOR], 0.60; 95% CI, 0.45-0.78), with short sleep duration of ≤ 6 hours/night (aOR, 0.71; 95% CI, 0.59-0.85) and long sleep of ≥ 9 hours/night (aOR, 0.53; 95% CI, 0.33-0.84), compared with persistently nonactive subjects.

  • Those who were persistently active were 22% less likely to report any symptoms of insomnia, 40% less likely to report two symptoms, and 37% less likely to report three symptoms.

  • Daytime sleepiness and difficulties maintaining sleep were found to be unrelated to physical activity status.

IN PRACTICE:

"This study has a long follow-up period (10 years) and indicates strongly that consistency in physical activity might be an important factor in optimizing sleep duration and reducing the symptoms of insomnia," the authors wrote.

SOURCE:

Erla Björnsdóttir, of the Department of Psychology, Reykjavik University, Reykjavik, Iceland, was the co-senior author and corresponding author of the study. It was published online on March 25 in BMJ Open.

LIMITATIONS:

It's unclear whether individuals who were active at both timepoints had been continuously physically active throughout the study period or only at those two timepoints. Sleep variables were available only at follow-up and were all subjectively reported, meaning the associations between physical activity and sleep may not be longitudinal. Residual confounders (eg, mental health and musculoskeletal disorders or chronic pain) that can influence both sleep and exercise were not explored.

Source: https://www.medscape.com/viewarticle/regul...

Red LEDs/Laser are all the rage. Do they do anything?

I’m sure you’ve seen the advertisements – Red light facemasks for skin rejuvenation, Red light helmets for fighting baldness, Red light wands for spot skin treatments, lasers for everything.  They must be good, right?

Turns out we’re back to my two favorite words:  IT DEPENDS.  

Let’s back up – why should we even consider these options?  

Let’s start with a little basic science and a thought experiment (don’t worry – it won’t hurt!)

You probably didn’t know that chlorophyll (stuff that makes plants green) and hemoglobin (the stuff that makes blood red) only differ in their central atom (cation) – magnesium for plants, iron for animals.  In plants, that molecule takes energy from the sun and allows the plant to store energy as growth (think vegetables).  In animals, that molecule (as commonly described) allows oxygen to be delivered to cells.  

But, there’s another part to this story.

Ever say “I need to go get some sun, so I can RECHARGE”?  There is evidence to show that going out in the sun does more than increase your Vitamin D levels – it actually (literally) charges your battery.  If we think of the body as kind of a battery, the whole analogy above starts to make more sense.  This has broad implications that we can discuss at another time.

So what if hitting the body with the appropriate light energy could deliver important inputs to push the body to do more restoration or the like, pushing energy into the system to do more of what would be good for it?  Not that far-fetched.  

The caveats are, of course, what kind of energy is right?  How it’s delivered, how intense, how long, over what area, etc., etc.  It can get pretty complicated, pretty fast.  

I have a pre-programmed handheld high-powered laser that allows me to treat all kinds of issues with very positive results, ranging from pain control to viral therapies.  We could even develop a protocol to treat your issues!  

Happy to have a conversation to discuss what FeldMed might have to offer to help bring you along the road to Limitless Healing!

In the mid-1960s, a Hungarian physician named Endre Mester shined a low-power laser on the shaved skin of a mouse. Though he was testing for impacts on tumor growth, he observed an unexpected side effect—the red light seemed to stimulate hair regrowth and, in later studies, wound healing.

Sixty years later, this accidental discovery has found its way into a booming market for clinical procedures and at-home devices using light-emitting diodes (LEDs).

Also possible with cold lasers, "low level" or "low power" light therapy requires a certain power level (measured in milliwatts per centimeter) to be effective, without the damaging heat of high-powered lights. From face and full-body masks to portable wands, low-level light therapy products promise all sorts of anti-aging, rejuvenating, and wound-healing benefits. 

“There’s a lot of hype in the industry,” says Daniel Barolet, a dermatological laser therapy researcher and clinician, and an adjunct professor at McGill University.

But are these devices—which can cost hundreds, even thousands of dollars—worth the price? Experts discuss the benefits and limitations of light therapy, and what consumers should know before making the investment. 

In the decades since Mester’s groundbreaking mice trials, research and development of phototherapy has taken off—with promising results.

Today, LED light therapy, or “photobiomodulation” (PBM) as it’s more accurately known, uses gentle, low-level light within the visible spectrum—typically blue, red, or near-infrared—to stimulate natural physiological processes. Or, as Barolet says, PBM just means “using light to give our cells a little nudge in the right direction.”

For much of human history, we would have gotten these benefits directly from the sun—but now we’re spending more time inside, with often cool-toned indoor lighting.

“When we're using photobiomodulation, we just cut the bad UV rays. We're just using the healing stuff,” Barolet says. “It’s biomimicking, but you harness what’s good for your skin, and you delete what’s not good for your skin.”

Light therapy devices found in clinics are generally more powerful, producing better and faster results. But for those who want to do their treatment at home, there’s a market full of options. 

While the exact mechanisms are not yet fully understood, PBM therapy has been shown to produce a range of positive effects. Blue light, for instance, can be used to treat acne and may mitigate other skin disorders by reducing inflammation. When blue light is absorbed by the skin, it activates the production of toxic free radicals which, over the course of several days, kill off the acne-causing P. acnes bacteria.

Glynis Ablon, a dermatologist and associate clinical professor at UCLA, says she’s seen dramatic effects in her patients undergoing blue light therapy. “What they'll notice, just from these LEDs alone, is that their acne gets better, that the level of inflammatory lesions reduces, that their overall skin just starts to look better.”

Red and near-infrared light, on the other hand, have longer wavelengths that can target the skin cells or travel deeper into the body. When light in this range penetrates the cells, Barolet says, it “kicks off a chain reaction” in the mitochondria. This metabolic process produces several important molecules, including ATP and nitric oxide, that are critical for basic bodily functions like energy production and healthy blood flow. 

The application of red and near-infrared light has a domino effect, stimulating collagen production and blood circulation. On a surface level, this can speed healing of wounds, such as burns or ulcers, and even reduce signs of aging, like wrinkles and brown spots.

While the skin is the largest and most visible organ in the body, all cells theoretically can enjoy a boost from red or near-infrared light therapy.

Generally speaking, the tissues that will improve the most are those in a state of depletion or disorder—such as sunburnt skin—according to Alexander Wunsch, a physician and photobiology expert. Of course, light therapy isn’t a panacea for treating skin or any other conditions. 

“There is real science to it and it does work clinically,” says Zakia Rahman, a clinical professor of dermatology at the Stanford School of Medicine, “but it’s not going to have the level of dramatic effect that more aggressive treatments in a medical setting would have.” 

Still, LEDs have distinct benefits—they’re non-invasive, pain-free, and essentially harmless. Prolonged exposure to blue light, which is near the UV spectrum, may cause skin damage, aging or irritation, but long-term research is still limited. With red and near-infrared, the only potential concerns are for those with sun allergies or highly sensitive eyes, according to Barolet.

“Think of photobiomodulation like your morning cup of coffee…but with light,” Barolet says. “It's like a wake-up call that gets all those tiny cellular processes up and running, helping the body to repair, rejuvenate, and energize itself.”

Clinics around the world offer PBM therapy for all sorts of cosmetic and medical purposes. Office devices are generally more powerful, producing better and faster results. But for those who want to do their treatment at home, there’s a market full of options. 

When it comes to choosing an LED device, experts agree that the most meaningful factor to consider is the output intensity.

“There’s a lot of scams out there…most of the time, energies are very, very low,” Ablon says. For red light, she looks for devices that emit 105 milliwatts per centimeter, but for blue light, the intensity can be lower. “If it’s somewhere in that 40 range, I’m ok, but if it ends up being 10, it’s probably not doing anything.”

Barolet also warns consumers to avoid devices that promote “a rainbow” of lights, such as green, yellow, and purple. When it comes to health, he says, the only wavelengths proven to be effective are red, near-infrared, and blue.

At-home light treatment can be performed with a variety of devices, including a shield-like mask (left) and wand (right).

It’s important to note that not all LED products on the market have been greenlit by the FDA. Wunsch advises consumers to look for 510(k) Clearance, “which gives you at least the information that this device has been evaluated”—though not tested—by the FDA for safety and effectiveness.

Barolet notes that, while the research supporting light therapy is robust, scientists are still perfecting their “recipe”—the ideal wavelengths, dosage, intensity, and proximity—for different health goals. In some cases, LED therapy works best in concert with other interventions, like pairing red light treatment with anti-aging cream, he says. While not a replacement for products like sunscreen or prescription retinoids, Rahman says that LEDs “can work well in your entire skin regimen.”

Ultimately, whether undergoing a clinical procedure or using at-home masks, experts advise people to stay the course of the treatment and not expect immediate results. While wound healing can happen faster, Wunsch says, the effects on healthy, normally aging skin can be slow and cumulative.  “You have to invest in the compliance in the first phase, and you will get your rewards in five or ten years.”

Source: https://www.nationalgeographic.com/science...

Study Throws Wet Blanket on Intermittent Fasting / Time Restricted Eating?

Everybody has heard of intermittent fasting / time restricted eating, right?  If not, it’s when you spend more time NOT eating than you do eating (think overnight fast – hence, Break-FAST).  It’s pretty clear that there are significant benefits to NOT eating for over 12 hours – the body has time to clear stuff out and potentially rebuild while not digesting food.  

The new study shows that when you push the NOT EATING window to 16 hours, you may be asking for trouble.  While the study is observational and has many limitations, the results are approaching astounding.  Risks of dying are significantly increased between 90 and 300%, depending on your baseline conditions.  If you’ve got cancer, the 8 hour or less feeding window translated to a 3 times greater risk of dying.  YIKES!

While I’m a big proponent of time restricted eating, I have always cautioned against the extremes here.  I’ve always thought that, on average, the optimal feeding window is around 10 hours – a 14 hour overnight fast (stop eating at 8, breakfast at 10).   For women, anything more than that seems to regularly make them feel worse.  Guys can tolerate longer, but this study has to make one wonder if that’s a good idea.  

As usual, the right answer will fall into the “it depends” category.  Individualized approach is always the best, but these data are hard to ignore, despite their limitations.

Intermittent Fasting Linked to Higher CVD Death Risk

A new study raises a cautionary note on time-restricted eating (TRE), a type of intermittent fasting that is gaining popularity.

The observational analysis of over 20,000 US adults showed that those who limited their eating to a period of less than 8 hours per day had a higher risk for cardiovascular mortality compared with peers who ate across the typical 12-16 hours per day. This was the case in the overall sample and in those with cardiovascular disease (CVD) or cancer.

Lead author Victor Wenze Zhong, PhD, cautioned that the findings "require replication and we cannot demonstrate 8-hour TRE causes cardiovascular death in this observational study."

"However, it's important for patients, particularly those with existing heart conditions or cancer, to be aware of the positive association between an 8-hour eating window and cardiovascular death," Zhong, professor and chair, Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China, told theheart.org | Medscape Cardiology

The results (Abstract P192) were presented March 18 at the American Heart Association (AHA) Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2024.

'Provocative' Results 

Short-term randomized controlled trials have suggested that 8-hour TRE may improve cardiometabolic risk profiles, but the potential long-term effects of this eating pattern are unknown. 

The observation that TRE may have short-term benefits but long-term adverse effects is "interesting and provocative" and needs further study, Christopher D. Gardner, PhD, professor of medicine at Stanford University in California, who wasn't involved in the study, said in a conference statement, and he agreed that much more research is needed. 

The researchers analyzed data on dietary patterns for 20,078 adults (mean age, 48 years; 50% men; 73% non-Hispanic White) who participated in the 2003-2018 National Health and Nutrition Examination Surveys (NHANES). All of them completed two 24-hour dietary recall questionnaires within the first year of enrollment. Deaths through the end of 2019 were determined via the National Death Index.

During a median follow-up of 8 years, there were 2797 deaths due to any cause, including 840 CV deaths and 643 cancer deaths. 

In the overall sample, compared with an eating duration of 12-16 hours, 8-hour TRE was significantly associated with an increased risk for CV mortality (hazard ratio [HR], 1.91; 95% CI, 1.20-3.03).

This association was also observed in adults with CVD (HR, 2.07; 95% CI, 1.14-3.78) and adults with cancer (HR, 3.04; 95% CI, 1.44-6.41). 

Other eating durations were not associated with CV mortality, except for eating duration of 8 to less than 10 hours in people with CVD (HR, 1.66; 95% CI, 1.03-2.67). 

No significant associations were found between eating duration and all-cause or cancer mortality in the overall sample and CVD/cancer subsamples, except that eating duration of more than 16 hours was associated with a lower risk for cancer mortality in people with cancer (HR, 0.47; 95% CI, 0.23-0.95).

Quality More Important Than Timing 

Zhong noted that the study doesn't address the underlying mechanisms driving the observed association between 8-hour TRE and CV death. 

"However, we did observe that people who restricted eating to a period less than 8 hours per day had less lean muscle mass compared with those with typical eating duration of 12-16 hours. Loss of lean body mass has been linked to higher risk of cardiovascular mortality," Zhong said. 

"Based on the evidence as of now, focusing on what people eat appears to be more important than focusing on the time when they eat. There are certain dietary approaches with compelling health benefits to choose, such as DASH diet and Mediterranean diet," Zhong told theheart.org | Medscape Cardiology.

Intermittent fasting is "certainly an interesting concept and one on which the potential mechanisms underlying the improvements in short outcome studies and preclinical studies in animals are strongly being pursued," Sean Heffron, MD, cardiologist at the Center for the Prevention of Cardiovascular Disease at NYU Langone Heart, New York, NY, who wasn't involved in the study, told theheart.org | Medscape Cardiology

Heffron expressed skepticism about the study results calling them "far from complete" and noted that data on diet was based on only 2-day diet records without correction for confounding variables. 

Heffron also noted that the restricted diet group has more smokers and more men. "I would "strongly anticipate that once appropriate corrections are made, the findings will no longer persist in statistical significance," Heffron said.

He emphasized the need for more rigorous research before making clinical recommendations. When patients ask about intermittent fasting, Heffron said he tells them, "If it works for you, that's fine," but he doesn't provide a recommendation for or against it. 

Source: https://www.medscape.com/viewarticle/inter...

Vitamin D -- it's not about COVID anymore

Vitamin D has been the source of some controversy for some time now.  Years ago there was debate about whether we should measure it at all (still some camps out there holding to that) because it wasn’t shown to relate to any clear diseases, increased risk, or if supplementing it made a difference.  More recently, COVID demonstrated that those with low vitamin D levels were more likely to end up in the Intensive Care Unit (86% of ICU COVID patients had low levels – under 29), and thus more likely to die.  Lots of people argued that supplementing vitamin D as prophylaxis against serious illness (including myself) was a good idea, but conventional evaluations of that didn’t yield confirmatory results (some studies were poorly done, but others were done well).  It makes for a bit of a morass when you’re trying to decide what to do.  For the record, my normal vitamin D level (25-OH to be specific) tends toward the low side, so I supplement daily.  

Now we have a review of small group of sedentary, nonsmoking Spaniards who had a bunch of metabolic parameters measured and compared.  What it showed was an inverse relationship between Vitamin D levels and virtually every cardiovascular risk factor you can think of . In other words, Vitamin D goes down, everything else bad goes up.  Their argument is that we could measure Vitamin D levels as an easy way to monitor cardiovascular risk.  Of course, in the US, to have the Vitamin D levels paid for by insurance companies, you have to be diagnosed with a Vitamin D disorder!  Ahhh, the beauty of American medicine.

By the way, I measure Vitamin D in everyone regularly.   It’s inexpensive to supplement, easy to avoid the virtually unheard of problems associated with excessive Vitamin D, and it just might avoid problems in the 300 or so mechanisms for which Vitamin D is essential.  

Concerned about your cardiovascular risks?  We have cutting edge approaches to evaluating and managing those risks, and establishing the presence of real issues before they become problems.  Let’s discuss your situation – first conversation is complementary.

From medscape / by Shrabasti Bhattacharya

Low Vitamin D Levels May Signal CVD Risk in Young Adults

TOPLINE:

Circulating levels of serum 25-hydroxyvitamin D (25[OH]D) may be a marker of cardiovascular disease (CVD) risk in healthy young adults, small study finds.

METHODOLOGY:

  • A secondary analysis of the Activating Brown Adipose Tissue Through Exercise (ACTIBATE) trial assessed the association between serum 25(OH)D levels and CVD risk factors.

  • The cross-sectional study used baseline data of in 177 healthy sedentary adults ages 18-25 years (65% women; all White individuals), who were recruited between October 2015 and December 2016 from Granada, a region in the south of Spain.

  • Study participants were nonsmokers, led a sedentary lifestyle, and did not have a prior history of CVD or chronic illnesses.

  • The CVD risk factors included anthropometrical and body composition profiles, glucose and lipid metabolism, liver, and pro- and anti-inflammatory biomarkers.

  • 25(OH)D serum concentrations were measured with a competitive chemiluminescence immunoassay and defined as deficient (< 20 ng/mL), insufficient (21-29 ng/mL), or normal (> 30 ng/mL).

TAKEAWAY:

  • The vitamin D levels correlated inversely with body mass index (BMI; standardized regression coefficient [β], −0.177; P = .018), fat mass index (β, −0.195; P = .011), and systolic blood pressure (β, −0.137; P = .038), after adjusting for sex.

  • Glucose metabolism markers (serum glucose and insulin concentrations, insulin/glucose ratio, and homeostatic model assessment of insulin resistance index) also correlated inversely with vitamin D levels.

  • The trend was similar for liver markers serum γ-glutamyl transferase and alkaline phosphatase) and the anti-inflammatory marker interleukin-4.

  • BMI, waist/hip ratio, fat mass index, blood pressure, and levels of glucose, insulin, triglycerides, and liver markers were higher in the 44 participants with vitamin D deficiency vs 41 participants with normal vitamin D levels.

IN PRACTICE:

"Collectively, these findings support the idea that 25(OH)D concentrations may be used as a useful marker of CVD status, which can be easily monitored in young individuals," the authors wrote.

SOURCE:

This study was led by first author Francisco J. Amaro‑Gahete, MD, PhD, from the Department of Physiology, Faculty of Medicine, University of Granada, Spain, who also holds positions in other institutions. It was published online on January 4, 2024, in the Journal of Endocrinological Investigation.

LIMITATIONS:

This study could not establish causal relationships due to its cross-sectional design. The results might not apply to younger or older people from different locations and ethnic backgrounds. The gold standard method for analyzing vitamin D levels, liquid chromatography–mass spectrometry, was not used in this study.

DISCLOSURES:

This study was supported by the Spanish Ministry of Economy and Competitiveness, Spanish Ministry of Education, AstraZeneca HealthCare Foundation, and other sources. The authors declared no conflicts of interest.

Source: https://www.medscape.com/viewarticle/low-v...

Itching can be a real *itch

Itching is a real problem for many people.  We all get an itch periodically, and if you’re lucky, you scratch it and it goes away. 

SIDE NOTE: Itching is on of human’s most noxious – worst – stimuli.  We scratch because the pain induced from scratching is less problematic for us than the itch.

There are, however, people who have a chronic itch.  This article discusses some of the treatment options they try, and I have to laugh a bit.  The expert is from John Hopkins Itch Center – clearly one of the premier institutions in the world, and yet, there is NO discussion of identifying and removing the cause of said itch!  The symptoms and the world is a better place – UNTIL THE NEXT TIME!  Seriously?

There are some conditions that, even in conventional medicine, are known to cause itch – allergic reactions, thus you take an anti-histamine.  But it can be much more that allergies.

Let’s think about how the body handles stuff that no longer belongs in the body – waste products of all kinds.  If something is supposed to be disposed of through the bowels or the kidneys, but the system isn’t up to that (for any number of reasons we won’t go into here), the body will try an alternative path.  That path could be through the skin (think sweating).  But it that “stuff” isn’t supposed to go through the skin, the body might react – sometimes with a rash, but sometimes simply with an itch.  If you can “open up” the correct path (colon or kidney for example), you can get the rash to go away.  I have plenty of folks for whom this approach works and works well.  

My logo is about coming out of the box – I suggest the box discussed here is still a bit too small.

FROM MEDSCAPE MEDICAL NEWS / By Damian McNamara

Think Outside the Traditional Toolbox to Treat Itch

"Itch may not be as sexy as Mohs surgery or aesthetic procedures," but treating it is important and meaningful to patients, particularly those who've found little relief previously, Shawn G. Kwatra, MD, said at the annual ODAC Dermatology, Aesthetic & Surgery Conference.

Chronic itch is common, with presentations that range from annoying to debilitating. There are many over-the-counter and prescription treatments patients can and likely have tried by the time they seek a dermatologist for help.

In doctors' defense, it can be highly challenging to know which approach is optimal for each individual with pruritus, added Kwatra, associate professor of dermatology at Johns Hopkins University, Baltimore, Maryland.

Cooling agents, topical capsaicin, topical anesthetics like pramoxine 1%, various forms of lidocaine, strontium, opioid modulators like naltrexone, oral Janus kinase inhibitor (JAK) inhibitors, and medical marijuana are among some of the "outside the box" tools in Kwatra's itch toolbox.

Often a Medical Puzzle

Frequently, patients come to the dermatologist complaining of itch, "but you don't see much on their skin." After a trial of antihistamines, and some topical steroids, the doctor might put up their hands and think: I tried, but I don't know what else to do. "This actually happens a lot," said Kwatra, who is also director of the Johns Hopkins Itch Center.

This means itch can frustrate providers as well. But for patients, the impact on their quality of life can be on the same level as recovering from a stroke or living with heart failure, Kwatra said. Finding relief for their itch is where "we can make a big difference for patients."

Consider Cooling Agents

Many of these therapies are inexpensive and widely available. Cooling agents like menthol, camphor, or calamine can reduce activity of the transient receptor potential (TRP) channels in the skin associated with itch. This ion channel also senses temperature, pressure, and other sensations.

Another option is topical capsaicin, which works through the same ion channels. It binds to the TRPV1 receptors in sensory nerve fibers and causes desensitization. Initially, four to six applications a day are required to reduce itch. After that, patients can apply the medication less frequently. "You have to tell folks we know it's going to work, but it's going to burn a lot initially," Kwatra said. "In real world practice, I'm not using it often."

A 1.8% capsaicin patch, approved for treating postherpetic neuralgia, can be used to treat pruritus as well. "You put the patch on for one hour and you can have a true clinical response," he noted.

Another option for itch relief, the topical anesthetic pramoxine 1%, "is probably underutilized for our patients," Kwatra said. Pramoxine 1% works fast — as quickly as 2 minutes — and lasts up to 8 hours and is well-tolerated with low toxicity, he added. The agent is applied three to four times a day and relieves itch by reducing the transmembrane permeability of sodium ions on the skin. "This is something widely available and cheap."

Lidocaine, another topical anesthetic, is available compounded, over the counter, and as a spray or patch. "I would be careful before you use high doses, like 10%" because of tolerability issues, Kwatra cautioned. He generally starts with lower concentrations.

Topical strontium is really interesting as a strategy, Kwatra said. Strontium is a soft, white metal that competes with calcium for receptor binding. There are over-the-counter formulations available as a scalp solution or lotion, which, he said, "are ways to go with more episodic itching."

Topical oatmeal can also relieve itch in some patients. "There is actually some good scientific evidence for topical oatmeal preparations," he said.

Steroid-Sparing Novel Topicals

Topical ruxolitinib (a JAK inhibitor approved for atopic dermatitis and vitiligo); topical roflumilast (a phosphodiesterase-4 inhibitor) and topical tapinarof (an aryl hydrocarbon receptor agonist), both approved for treating psoriasis; and the atopic dermatitis drug crisaborole fall into this category of topicals with potential for treating itch, he said, noting that use for treating itch is off label.

Off-label use of biologic agents are also possible treatment options for itch, dupilumab and tralokinumab, both US Food and Drug Administration (FDA)–approved for treating atopic dermatitis. Emerging agents that may prove useful for treating itch include lebrikizumab, nemolizumab, amlitelimab, and rocatinlimab, he said.

In terms of oral therapies, the FDA has approved two oral JAK inhibitors for atopic dermatitis, abrocitinib and upadacitinib, which could prove useful for itch as an off-label indication, according to Kwatra.

Naltrexone Off Label

An emerging therapeutic concept for treating itch is using an opioid antagonist like naltrexone. Morphine causes more itch, so the theory is a reversal agent might help reduce it. The challenge is that naltrexone only comes as a 50 mg tablet, "and I find the high dose makes people nauseous and vomit," he added.

Don't Forget Devices

He referred to a "great paper" that he said has been "totally overlooked," published in 2001, which evaluated a device that stimulates C fibers in the skin to reduce itch. In the study, 19 patients used the device to treat local areas 20 minutes daily for 5 weeks. Punch biopsies of the affected areas were taken at baseline and after treatment. Mean itch ratings decreased from 78% to 42%, and the number of immunoreactive nerve fibers in the epidermis decreased by 40% at the end of treatment.

"Electrical neurostimulation is better for localized pruritus. There is limited case series evidence, but it's something to think about," Kwatra said.

He and his colleagues also have a case study in press that explored the use of injected botulinum toxin to relieve recalcitrant, chronic itch in a 65-year-old man "who failed everything."

Source: https://www.medscape.com/viewarticle/think...

If you want to save lives, you've got to catch it early. But is it worth it?

Ovarian Cancer is not something I spend a lot of time working on, but it’s a terrible disease, mostly because it’s usually diagnosed very late, making it very difficult to successfully treat.  Sure, the BRCA gene story has segment some of those people, but then they’re having prophylactic surgery (removal of breast and/or ovaries) to avoid the future possibility of cancer.  One would think that a better option is needed.

The study presented is really interesting in how effective it is at identifying early disease and thereby limiting surgical removal of actual diseased organs and effecting cures.  A simple blood test done regularly over time can screen people and help target those with hints of problems, escalating interventions as required.  This approach clearly works, and actually works very well.  

Now the problem is the money.  How much does it cost to save someone’s life?  There is a metric known as QALY (Quality Adjusted Life Year) that’s used to calculate the “value” of an intervention.  Sometimes the calculation gets very complex, but it usually only takes into account the health care costs, not the societal costs, so it’s not always a great way to measure “value”.  A standard, conservative figure for QALY value is $50,000.  That means that a treatment would cost $50,000 for every year of life saved.  Some inexpensive blood pressure medications come in around $15-30,000; an annual screening mammogram for women over 50 works out around that $50k number.  The challenge comes in when you stretch the target audience – for women over 40, the number rises to around $200k.  In the case of screening for prostate cancer, there’s never been a figure calculated because it’s not clear screening actually saves lives, but that’s another story.

Here we have a very clear option for screening that is very good at finding the target.  It now will have to wait for the economics to be determined and whether or not saving these lives “is worth it”.

From the Journal of Clinical Oncology / By Chae Young Han, PhD, Karen H. Lu, MD, Gwen Corrigan, Alexandra Perez, CMA, Sharlene D. Kohring, HSD, Joseph Celestino, BS, Deepak Bedi, MD, Enrique Bedia, MD, Therese Bevers, MD, David Boruta, MD, Matthew Carlson, MD, Laura Holman, MD, Leroy Leeds, MD, Cara Mathews, MD, Georgia McCann, MD, Richard G. Moore, MD, Matthew Schlumbrecht, MD, Brian Slomovitz, MD, Dan Tobias, MD, Yvette Williams-Brown, MD, Michael W. Bevers, MD, Jinsong Liu, MD, Terrie G. Gornet, BS, Beverly C. Handy, MD, Zhen Lu, MD, Jacob S. Bedia, BS, Steven J. Skates, PhD, and Robert C. Bast Jr, MD

Abstract

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.

Purpose

The Normal Risk Ovarian Screening Study (NROSS) tested a two-stage screening strategy in postmenopausal women at conventional hereditary risk where significantly rising cancer antigen (CA)-125 prompted transvaginal sonography (TVS) and abnormal TVS prompted surgery to detect ovarian cancer.

Methods

A total of 7,856 healthy postmenopausal women were screened annually for a total of 50,596 woman-years in a single-arm study (ClinicalTrials.gov identifier: NCT00539162). Serum CA125 was analyzed with the Risk of Ovarian Cancer Algorithm (ROCA) each year. If risk was unchanged and <1:2,000, women returned in a year. If risk increased above 1:500, TVS was undertaken immediately, and if risk was intermediate, CA125 was repeated in 3 months with a further increase in risk above 1:500 prompting referral for TVS. An average of 2% of participants were referred to TVS annually.

Results

Thirty-four patients were referred for operations detecting 15 ovarian cancers and two borderline tumors with 12 in early stage (I-II). In addition, seven endometrial cancers were detected with six in stage I. As four ovarian cancers and two borderline tumors were diagnosed with a normal ROCA, the sensitivity for detecting ovarian and borderline cancer was 74% (17 of 23), and 70% of ROCA-detected cases (12 of 17) were in stage I-II. NROSS screening reduced late-stage (III-IV) disease by 34% compared with UKCTOCS controls and by 30% compared with US SEER values. The positive predictive value (PPV) was 50% (17 of 34) for detecting ovarian cancer and 74% (25 of 34) for any cancer, far exceeding the minimum acceptable study end point of 10% PPV.

Conclusion

While the NROSS trial was not powered to detect reduced mortality, the high specificity, PPV, and marked stage shift support further development of this strategy.

Source: https://ascopubs.org/doi/10.1200/JCO.23.00...

Weight Loss Drugs Often Stall

Most people are familiar with the concept of a weight setpoint.  The setpoint is the body’s somewhat “natural” weight – seems like we always drift back to a particular number.  When we diet, if we get too severe in our restriction, the body moves into a kind of starvation state, our energy utilization (fat burn) drops and we hang onto the weight.  And we slowly drift back to where we were (unless you’ve yo-yo’d so much that you actually end up drifting even higher).  It’s really hard to reset our set points.  

The new GLP-1 weight loss medications – Wegovy, Ozempic, Mounjaro have proven themselves to be very helpful for many, if not most people.  Most overweight people (that’s nearly ½ of America) have some measure of insulin resistance, and thus these medications make sense, and work.  Of course, like all medications, there can be side effects, and some can be really severe.  Even so, they are a tremendous step forward for many, many people who have struggled with their weight.

As many of us would have expected, it appears that the GLP-1 meds may not be able to eliminate the set point problem.  It is likely that most people will be able to RESET their set points to a lower number, then seemingly virtually everyone will plateau.  This is no surprise – a metabolic process will work according to the overall environment.  Likely the situations that influenced the weight gain in the first place will continue to have some sway of the future.  

It doesn’t mean that people should avoid the medication.  If there’s a good reason to start it, it’s worth the try.  Only understand that the weight loss rainbow may not end in a kettle of gold.  Though for many, it’s a lot more than spare change!

FROM MEDPAGE TODAY/ BY SOPHIE PUTKA

The GLP-1 Agonist Plateau No One's Talking About

— Weight stabilization is no surprise to specialists, but for patients it's more complicated

The declines in body weight that patients experience with injectables like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) are no exception to the concept that nothing lasts forever.

Eventually, everybody reaches a "plateau," even on newer GLP-1 receptor agonists. It's a phase at which the body reaches a new "settling point," specialists said, and weight, along with other metabolic markers like blood pressure and HBA1c stabilize, or fluctuate only slightly. For some, this may mean a gradual increase in appetite or "food noise"; others may be able to maintain their current state.

Studies have shown that, on average, this plateau happens at a little over a year with semaglutide. Even so, physicians say some patients are surprised to learn that there's a limit to what these medications can do.

"Everyone will plateau, of course. No one on my watch has disappeared. No one has vanished," Jody Dushay, MD, an endocrinologist at Beth Israel Deaconess Medical Center in Boston, told MedPage Today. "It's alarming to me that people find that surprising, but everyone will reach a plateau and there's no way to know when you start the medication what that will be, what percent weight loss that will be, and how quickly they will reach it."

Gitanjali Srivastava, MD, an obesity medicine specialist at Vanderbilt University Medical Center in Nashville, Tennessee, noted that "we see that often and it's a question that gets asked frequently. There's going to be a new homeostatic balance that's achieved, and we see that with any other disease phenomenon."

For example, Srivastava told MedPage Today that a patient will not become hypotensive after a certain amount of time on a blood pressure medication, or have blood glucose levels decrease indefinitely with diabetes medications. "Evolutionarily, we need to be able to do that, so we can protect against the extremes," she added. "Because the alternative is that you continue to wither away, and that can be dangerous."

It's still unclear what may predispose patients to longer or shorter responses to GLP-1 agonists, but Dushay said that, typically, early responses tend to predict later ones. If a patient experiences steep weight loss on lower doses of semaglutide, for example, they can stay on a lower dose for longer, with more time to uptitrate if necessary. Patients on semaglutide for type 2 diabetes also tend to experience less weight loss overall, she said.

Karl Nadolsky, DO, an endocrinologist and obesity medicine specialist at Holland Hospital in Michigan, told MedPage Today in an email that "a history of childhood obesity with any suspicion [of] specific genetic or syndromic etiology" might also hint at a predisposition to hyporesponse.

Specialists have said that before prescribing this class of medication, they thoroughly discuss what to expect, from side effects to plateauing and the possibility of non-response. Dushay noted that it's important that providers set these expectations with patients, and for patients to seek out doctors who have the time and clinical experience to do so.

In clinical trials that looked at semaglutide 2.4 mg per week, participants' weight loss tapered off around week 60, with about 10% to 15% of body weight lost. Semaglutide's effect on blood pressure and HBA1c appeared to plateau even earlier. Spanning 2 years, patients hit a weight plateau once again around 60 weeks, and were able to maintain that weight for the remainder of the study. In the Surmont Trial which looked at various doses of tirzepatide for 72 weeks, participants on the 5-mg dose had reached a plateau within 60-72 weeks, but this was not the case on the higher doses. A 2-year trial is expected to offer more insight.

However, clinicians are more interested in what such averages hide. It's nearly impossible to know how well a patient will respond to semaglutide or tirzepatide, and individuals may have wildly different medical histories, medications, and comorbidities that all affect how well, and for how long, a given drug may work.

Fatima Cody Stanford, MD, MPH, MPA, MBA, an obesity medicine specialist at Massachusetts General Hospital in Boston, pointed out that a patient's expectation may not match their ultimate response to a GLP-1 agonist. "Everybody comes in and they're like, 'I want to do what this person did' -- they have their family, their friend, their sister, their brother, cousin, aunt, and I'm like, 'well, we don't know,'" she said. "The only people that I expect to respond almost identically are identical twins."

Stanford said she would like to see studies on GLP-1 agonists in the future that stratify patient response by various characteristics like genetics. Right now, she noted, weight-loss drugs require a lot of trial and error. Predicting the likelihood of success for individual patients would save time -- and money. "When a new cancer drug comes out, not everyone's like, 'ooh, there's a new cancer drug, let's just start everyone on that.' Right? Nobody does that," she said. "I want to know who the drug is right for."

"If I know that, on average, this person is going to be a really poor responder to a GLP-1 agonist, I won't [prescribe it]," she added. "It is a really arduous pathway for a lot of reasons -- access, coverage, prior authorization. It's burdensome. It's burdensome on the patient, it's burdensome on the system, it's burdensome on me."

Experts said it's common for patients to want more. For example, they may bring their blood glucose within a normal range, go off of blood pressure medications, and maintain overall positive health outcomes with a GLP-1 agonist, but hit a "plateau" and still want to lose weight.

Ultimately, this is where psychological and societal ambitions collide with clinical ones.

Patients are "having to negotiate with what society tells them, so they're still 200 pounds and society says 'for your height and weight you should be 125,' even though their health looks amazing," Stanford said. "Not always, but often, they still want to be whatever this number is."

Dushay said it's rare for patients to achieve the weight loss goal they arrive at an initial consult with. Often, Dushay's noticed, this goal is the weight they were on their wedding day. "I think that some of it is literally [that] they want to weigh that," she said. "But I think there is a big component of 'I want to rewind time.'"

"I've almost never had someone hit a plateau when they were like, 'okay, I'm good.'"

In the meantime, clinicians have strategies to move past a plateau if a patient hasn't yet met important clinical goals. Generally, some said they might increase the dose if possible, if the patient can tolerate it well. Failing that, they can supplement with a second drug that targets a different neuronal or hormonal pathway, like phentermine (Lomaira). Dushay said that in practice she's noticed that "drug holidays" or stopping and restarting a GLP-1 agonist, have typically not affected plateaus.

Source: https://www.medpagetoday.com/special-repor...

You didn't get Long COVID, but that doesn't mean it didn't do long term damage

Nearly everyone has had COVID by now.  If you got it early, you probably got it worse than others, but not necessarily.  Many people have suffered, and many people have continued to suffer.  Long COVID has recently be shown to have blood abnormalities (we knew that ages ago) that can prove “it’s not in your head”.  But more than that, every time one gets COVID, there’s a risk that bad things will happen – and persist.  Here’s a study that shows that if you get COVID you have 1.50 times the risk of having hypertension (high blood pressure) then if you didn’t get COVID, but if you were hospitalized for COVID, the risk of HBP goes up to 2.2x’s.  We’ve said this is a blood vessel disease, and this just bears it out. 

Don’t assume that everything is fine if you have COVID and you get over it.  Even Long COVID can be delayed by a couple of months!  Don’t assume – follow up with your doctor and make sure other problems don’t develop.

Incidence of New-Onset Hypertension Post–COVID-19: Comparison With Influenza

Abstract

BACKGROUND:

SARS-CoV-2 may trigger new-onset persistent hypertension. This study investigated the incidence and risk factors associated with new-onset persistent hypertension during COVID-19 hospitalization and at ≈6-month follow-up compared with influenza.

METHODS:

This retrospective observational study was conducted in a major academic health system in New York City. Participants included 45 398 patients with COVID-19 (March 2020 to August 2022) and 13 864 influenza patients (January 2018 to August 2022) without a history of hypertension.

RESULTS:

At 6-month follow-up, new-onset persistent hypertension was seen in 20.6% of hospitalized patients with COVID-19 and 10.85% of nonhospitalized patients with COVID-19. Persistent hypertension incidence among hospitalized patients did not vary across the pandemic, whereas that of hospitalized patients decreased from 20% in March 2020 to ≈10% in October 2020 (R2=0.79, P=0.003) and then plateaued thereafter. Hospitalized patients with COVID-19 were 2.23 ([95% CI, 1.48–3.54]; P<0.001) times and nonhospitalized patients with COVID-19 were 1.52 ([95% CI, 1.22–1.90]; P<0.01) times more likely to develop persistent hypertension than influenza counterparts. Persistent hypertension was more common among older adults, males, Black, patients with preexisting comorbidities (chronic obstructive pulmonary disease, coronary artery disease, chronic kidney disease), and those who were treated with pressor and corticosteroid medications. Mathematical models predicted persistent hypertension with 79% to 86% accuracy. In addition, 21.0% of hospitalized patients with COVID-19 with no prior hypertension developed hypertension during COVID-19 hospitalization.

CONCLUSIONS:

Incidence of new-onset persistent hypertension in patients with COVID-19 is higher than those with influenza, likely constituting a major health burden given the sheer number of patients with COVID-19. Screening at-risk patients for hypertension following COVID-19 illness may be warranted.

Source: https://www.ahajournals.org/doi/10.1161/HY...