Does your Heart have a "Brain"?

Never to be one that stays in my lane, here’s some obscurity that is not only interesting, but may have real implications down the road.

There’s lots of evidence that says the heart is the heart of everything – that’s why we call it the heart!  Discussions of interactions between heart and brain are fascinating – like why are there many more signals going from the heart to the brain than the other way around?  Is the heart in charge or the brain? 

A  “mini-brain” has been confirmed in the heart of a zebrafish (why a zebrafish?  Turns out it’s closer to a human heart than a mouse heart), and unlike what was previously believed, it functions independently from the brain.  This complex mini-brain can independently effect heart rate, but it’s more than that -- zebrafish neurons are known to produce substances that activate stem cells in bones, skin, and even the nervous system.  How will this information shake out?

Who knows – but I think it’s pretty cool! 

FROM MEDSCAPE / BY Tatum Anderson

The heart’s “mini-brain” is independent and highly localized, according to researchers at the Karolinska Institutet in Stockholm, Sweden. The findings could lead to new research into arrhythmia, dementia, and Parkinson’s disease.

Although controlled by the brain, the heart has a separate, smaller intracardiac nervous system (IcNS) embedded within the superficial layers of the heart wall. Nicknamed the mini-brain by researchers decades ago, the IcNS was assumed to be a simple structure capable only of relaying simple information from the brain to the heart.

The neurons in the mini-brain, however, have been under-researched, said Konstantinos Ampatzis, principal researcher and assistant professor of neuroscience at the Karolinska Institutet. “Cardiologists know that neurons exist but never study them because their first concern is the cardiac muscle cells, or cardiomyocytes, that are responsible for the heartbeat,” he explained. “Neuroscientists understand and decode neurons but don’t know about neurons in the heart.”

Ampatzis’s team mapped the exact composition, organization, and function of neurons in the IcNS using zebrafish as an animal model. “The heart of the zebrafish is closer to that of humans than the mouse heart is,” he explained. “The heart rate of a zebrafish is exactly the same.”

Several techniques were used to characterize these neurons. Electrophysiology determined their function, and researchers at Columbia University in New York City helped identify their molecular signatures using single-cell RNA sequencing. Ampatzis and his team also analyzed neurotransmitters that the neurons release to communicate with each other. Researchers in Sweden and New York worked on this project in their spare time because they had no additional funding.

Ampatzis expected to see ganglions or relay neurons capable only of receiving or sending information. “But we found a very diverse set of neurons in a small network,” he said. Their findings included sympathetic, parasympathetic, and sensory neurons with apparent neurochemical and functional diversity. Most surprising was a subset of pacemaker neurons. “You cannot have a network that produces a rhythm without these neurons, and we didn’t expect exactly that, to be honest,” he said.

Pacemaker neurons are usually associated with so-called central pattern generator networks within the central nervous system. These independent, highly localized neuronal networks generate and control complex rhythmic behaviors such as respiration, mastication, urination, and ejaculation. “Most importantly, we found that this neuronal network works in an isolated heart, without brain information, and can change the rhythm of the heart and the regularity by itself,” said Ampatzis.

Further studies confirmed that neurons do not produce the rhythm, which is controlled by the cardiomyocytes. The neurons’ main function is to regulate the speed of the heartbeat. In other words, this smaller localized network acts as a kind of insurance system to safeguard the brain’s control of the heartbeat. “From an evolutionary perspective, I think that the system is like this because the heartbeat defines life,” Ampatzis added.

With the neurons of the heart mapped, medical researchers now have a toolbox of molecular markers, neurotransmitters, and other information on how such neurons function. These findings could become the basis of new research. It might be possible to investigate heart arrhythmia by modulating pacemaker neurons, Ampatzis suggested. “You could even repurpose or find specific drugs that can interfere with this local network of the heart,” he said, adding that this might be a less invasive option than is possible today.

Arrhythmia affects millions of people, said Oliver Guttmann, MD, a consultant cardiologist at The Wellington Hospital and honorary associate professor of cardiology at University College London, both in London, England. Beta-blockers remain the drug of choice for arrhythmia, but other options can be invasive. “We do ablations to try and burn or freeze certain areas of the heart to get rid of a rhythm because often this comes from hyperactive cells somewhere,” he said. Pacemakers and defibrillators are also needed to modulate dangerous rhythms. Innovation is focusing on making interventions far less invasive than they are today by creating smaller and smaller pacemakers, for example.

Moving from zebrafish to more complex mammalian systems will be the next big step, said David Paterson, DPhil, head of the Department of Physiology, Anatomy, and Genetics and honorary director of Burdon Sanderson Cardiac Science Centre at the University of Oxford, Oxford, England. “If you can find the molecular road map of dysregulation, then that could be a potential target for a gene therapy or cell therapy or for neuromodulation therapy,” he explained. Interest in this field, which is sometimes called bioelectronic medicine, is mounting. “It’s like pharmaceutics, but there’s no drug. You’re tapping into the wiring of the nervous system,” he added.

More radical research pathways might look at ways to tackle neurodegenerative disorders from dementia to Parkinson’s disease. “If neurons die in the brain, then they die in the heart and can affect the rhythm of the heart,” said Ampatzis. But zebrafish neurons are now known to produce substances that induce a proliferation of stem cells in bones, skin, and even the nervous system. “We think those neurons of the heart could perhaps contribute to the regeneration of the heart,” he said.

Source: https://www.medscape.com/viewarticle/zebra...

How Sensitive is Blood Pressure to Exercise? Guess what -- It Depends!

Here’s an article from the UK looking at a big group wearing activity trackers and evaluating what makes a difference for blood pressure.  The original article in Circulation is chocked full of interesting stuff for the data geek, and not surprisingly complex interrelationships are discovered between different types of activity and the resulting blood pressure effects.  What’s tricky is that the data is always reported for the population, and a change of less than 1 counts as significant  (but that wouldn’t be significant for you!).  A couple of meaningful takeaways are:

  1. If you don’t get enough sleep, getting more sleep will make a significant difference, especially if you kick in exercise (climbing stairs, exercise at the gym, running for the bus – not just walking) along with it.

  2. If you are sitting around a lot (more than 10 hours a day), AND you get a lot of sleep, getting MORE SLEEP WILL RAISE YOUR BP!  Getting more exercise definitely drop lower your blood pressure.

  3. It’s going to take 20-27 minutes of exercise a day to move your top BP number (systolic) and 10-15 minutes a day to more your bottom number (diastolic)

You’ve heard me say it before – get moving!

FROM MEDSCAPE UK / BY Jenny Blair

TOPLINE: 

Meaningful blood pressure reduction can take place by re-allocating as little as 10 minutes spent in other activities over a 24-hour period to exercise-like activity.

METHODOLOGY: 

  • Analysis of pooled data from six cross-sectional cohort studies, the Prospective Physical Activity, Sitting, and Sleep consortium (ProPASS) collaboration.

  • Participants (n = 14,761) wore 24-hour movement trackers.

  • Devices totaled average daily time spent doing six activities: sleeping, sedentary time, standing, slow walking, fast walking, and exercise-like activity.

  • The outcome of interest was blood pressure.

TAKEAWAY:

  • Each extra 5 minutes of exercise-like activity was linked to slight but statistically reductions in systolic and diastolic blood pressure (−0.68 mmHg and −0.54 mmHg, respectively).

  • The above reductions were meaningful in reducing, eg, stroke risk on the population level.

  • Exercising instead of other activities for an average of 20-27 minutes throughout the course of the day was estimated to result in clinically significant systolic reductions for individuals.

  • Similarly, exercising instead of other activities 10-15 minutes was estimated to result in clinically significant diastolic reductions.

IN PRACTICE:

"The exercise-like activities modelled in our study encompassed activities such as running, cycling, or inclined walking, and could include both structured, intentional exercise, and incidental daily activities such as running for a bus or climbing stairs," the authors wrote.

SOURCE:

Conducted by the international ProPASS Consortium, the study appeared in Circulation.

LIMITATIONS:

Causation not established. Sleep quality was not measured. Sample was not ethnically or racially diverse. Duration of bouts of exercise was not considered, only the daily average.

Source: https://www.medscape.co.uk/viewarticle/exe...

One of the reasons I'm Out Of Network

I once worked in a provider organization that was high on limiting inappropriate services.  Unfortunately, they wanted the doctors to jump through as many hoops as possible (I was strongly opposed).  In this case, they wanted to require precertification for CT scans of the abdomen – at that point (20+ years ago) this kind of precert it was largely unheard of.  I said no from a purely business perspective -- the number of cases that would ultimately be denied would be so small that there would be no savings.  I lost the argument because it was felt that the hoop alone was enough to produce savings.  And that’s where we were until recently.  

Now, there’s AI that allows even the hoop to be restrictive enough so that the request is essentially denied almost before it was conceived of!  If you think you’re getting screwed by the insurance company – odds are that you are!   

The following article is scary.  But it effects almost 1/3 of this country.  YIKES!

I can help you figure out if what you’ve asked for is really necessary, if there are alternatives, or if you need to fight harder.  Doesn’t mean you can win, but sometimes IT IS life or death.

FROM PROPUBLICA / BY T. CHRISTIAN MILLER, PATRICK RUCKER, DAVID ARMSTRONG

“Not Medically Necessary”: Inside the Company Helping America’s Biggest Health Insurers Deny Coverage for Care

Reporting Highlights

  • Dialing for Dollars: America’s largest insurers hire EviCore to make decisions on whether to pay for care for more than 100 million people.

  • “The Dial”: EviCore uses an algorithm that allows it to adjust the chances that company doctors will screen prior authorization requests, increasing the possibility of denials.

  • Lucrative Deals: Some EviCore contracts are based on how deeply the company can reduce spending on medical procedures. It tells insurers that it can provide a 3-to-1 return on investment.

These highlights were written by the reporters and editors who worked on this story. Were they helpful?

Every day, patients across America crack open envelopes with bad news. Yet another health insurer has decided not to pay for a treatment that their doctor has recommended. Sometimes it’s a no for an MRI for a high school wrestler with a strained back. Sometimes for a cancer procedure that will help a grandmother with a throat tumor. Sometimes for a heart scan for a truck driver feeling short of breath.

But the insurance companies don’t always make these decisions. Instead, they often outsource medical reviews to a largely hidden industry that makes money by turning down doctors’ requests for payments, known as prior authorizations. Call it the denials for dollars business.

The biggest player is a company called EviCore by Evernorth, which is hired by major American insurance companies and provides coverage to 100 million consumers — about 1 in 3 insured people. It is owned by the insurance giant Cigna.

A ProPublica and Capitol Forum investigation found that EviCore uses an algorithm backed by artificial intelligence, which some insiders call “the dial,” that it can adjust to lead to higher denials. Some contracts ensure the company makes more money the more it cuts health spending. And it issues medical guidelines that doctors have said delay and deny care for patients.

EviCore and companies like it approve prior authorizations “based on the decision that is more profitable for them,” said Barbara McAneny, a former president of the American Medical Association and a practicing oncologist. “They love to deny things.”

EviCore says it scrutinizes requests to make sure that procedures recommended by doctors are safe, necessary and cost-effective. “We are improving the quality of health care, the safety of health care and, by very happy coincidence, we’re also decreasing a significant amount of unnecessary cost,” an EviCore medical officer explains in a video produced by the company.

But EviCore’s cost-cutting is far from coincidental, according to the investigation.

EviCore markets itself to insurance companies by promising a 3-to-1 return on investment — that is, for every $1 spent on EviCore, the insurer would pay out $3 less on medical care and other costs. EviCore salespeople have boasted of a 15% increase in denials, according to the investigation, which is based on internal documents, corporate data and dozens of interviews with former employees, doctors, industry experts, health care regulators and insurance executives. Almost everybody interviewed spoke on condition of anonymity because they continue to work in the industry.

An analysis of the company’s own data shows that, since 2021, EviCore turned down prior authorization requests, in full or in part, almost 20% of the time in Arkansas, which requires the publication of denial rates. By comparison, the equivalent figure for federal Medicare Advantage plans was about 7% in 2022.

EviCore has several ways to cut costs for insurers. Chief among them is the dial, the proprietary algorithm that’s the first stop in evaluating a prior authorization. Based on data entered by a doctor’s office, it can automatically approve a request.

The algorithm cannot say no, however. If it finds problems, it sends the request for review to a team of in-house nurses and doctors who consult company medical guidelines. Only doctors can issue a final denial.

This is where tweaking the dial comes in. EviCore can adjust the algorithm to increase the number of requests sent for review, according to five former employees. The more reviews, the higher the chance of denials.

Here’s how it works, the former employees said: The algorithm reviews a request and gives it a score. For example, it may judge one request to have a 75% chance of approval, while another to have a 95% chance. If EviCore wants more denials, it can send on for review anything that scores lower than a 95%. If it wants fewer, it can set the threshold for reviews at scores lower than 75%.

“We could control that,” said one former EviCore executive involved in technology issues. “That’s the game we would play.”

Over the years, medical groups have repeatedly complained that EviCore’s guidelines were outdated and rigid, resulting in inappropriate denials or delays in care. Frustration with the rules has led some doctors to refer to the company as EvilCore. There is even a parody account on X.

The guidelines are also used as a tool to cut costs, the investigation found. Company executives “would say, ‘Keep a closer eye on the guidelines for reviews for a particular company because we’re not showing savings,’” said a former EviCore employee involved in the radiation oncology program.

EviCore says that it develops its guidelines with the input of peer-reviewed medical studies and professional societies, and that they are routinely updated to stay current with the latest evidence-backed practices. It said its decisions are based solely on the guidelines and are not interpreted differently for different clients.

EviCore is not alone in engaging in the denials-for-dollars business. The second-biggest player is Carelon Medical Benefits Management, a subsidiary of Elevance Health, the health insurer formerly known as Anthem. It has been accused in court of wrongfully denying legitimate requests for coverage. The company has denied all charges. Several smaller companies do the same kind of work.

There is no question that prior authorizations play an important role in modern medicine. They serve to guard against doctors who recommend unnecessary and even potentially harmful treatments. They also protect insurers from fraudulent physicians who overbill for services.

In a response to questions, a Cigna spokesperson provided a statement on behalf of EviCore. “Simply put, EviCore uses the latest evidence-based medicine to ensure that patients receive the care they need and avoid the services they do not,” it said.

The statement acknowledged that EviCore used algorithms for some clinical programs, but “ONLY to accelerate approval of appropriate care and reduce the administrative burden on providers.”

The statement noted that doctors have the ability to appeal prior authorization denials, and that the company routinely monitors the outcomes “as part of our continuous quality improvement to ensure accurate and timely medical necessity decision-making.”

Prior authorization reviews provided by EviCore save money for the entire health insurance system, the statement said. “The natural product of improved care quality and reduced waste is savings for our clients, lower out-of-pocket costs for patients, and fewer health care premium increases for Americans.”

Turning the Dial

In the fall of 2021, when the air grew crisp and the leaves reddened in central Ohio, Little John Cupp began feeling short of breath. He gasped while pushing a shopping cart. His feet and ankles swelled. He could only sleep while sitting up.

An echocardiogram revealed that his heart was having trouble pumping blood. Cupp’s doctor suggested more testing, including the insertion of a catheter to examine whether his arteries were blocked.

A few days after the doctor made the request, Cupp received a letter from his insurance company, UnitedHealthcare. The procedure, it said, was “not medically necessary.”

Little John Cupp provided support for his family, including buying a new four-bedroom trailer. Credit:Courtesy of Chris Cupp

One sentence in 8-point type revealed that the insurer had outsourced the decision to EviCore.

Cupp’s doctor put him on medications to reduce swelling and high blood pressure and tried a second time to win approval for a left heart catheter examination. EviCore turned it down again. He revealed his disappointment in shorthand in Cupp’s medical records: “ideally he needs LHC (denied twice by insurance).”

Cupp was 5-foot-7 and 282 pounds, with a wedding ring the size of a quarter. He had a white beard, his face wide and warm. He wore blue jean overalls and scuffed leather work boots. He had spent most of his life as a welder, working at metal fabrication shops in and around his hometown of Circleville, Ohio, population 14,063. He was 61, nearly the same age as his father when he died from a massive heart attack. Cupp was a stoic, his daughter Chris said, but the denial worried him.

“Well, I have to call the doctor and see what we’re going to do,” he told her after the second rejection.

The doctor decided to give up on getting an approval for the catheter exam. In challenging EviCore, he was fighting not just a company but an industry.

EviCore is the product of a massive, decadeslong push by insurance companies to control health care costs. They point to studies that show 20% to 45% of some medical treatments are wasteful or ineffective. To decrease such spending, insurers began requiring doctors to seek permission for medical care before agreeing to pay for it — a process known as “utilization review.” As treatments became more complex, the reviews proved costly in themselves.

Created from a 2014 merger of two smaller companies, EviCore offered a solution: It allowed insurers to outsource prior authorization decisions for the most specialized and expensive procedures. EviCore today issues recommendations for imaging, oncology, cardiology, gastroenterology, sleep problems and many other fields.

It works with more than 100 insurers across the country, including industry titans such as UnitedHealthcare, Aetna and Blue Cross Blue Shield and some Medicare and Medicaid contractors. Cigna took over the company in 2018, but EviCore maintains its independence by blocking insurers from prying into one another’s proprietary data.

In responses to inquiries, the large insurance companies said they hired EviCore as a way to make sure that customers received safe and necessary medical treatments, while holding down costs for inappropriate care.

EviCore built its business by relying on different types of contracts. In one, a health insurance company pays EviCore a flat rate to review coverage requests.

Another type is more lucrative, providing an incentive for EviCore to cut costs, former employees said. Known as risk contracts, EviCore takes on the responsibility for paying claims. As an example, say an insurer spends $10 million a year on MRIs. If EviCore keeps costs below that figure, it pockets the difference. In some cases, it splits the savings with the insurance company.

“Where you really made your money was on a risk model,” a former EviCore executive said. “Their margins were exponentially higher.”

EviCore teams involved in developing the algorithms and contracting with clients “operate separately” from reviewers “to prevent any potential conflicts of interest,” according to the statement from Cigna’s spokesperson.

Insurers do not make explicit demands for more denials, a former EviCore sales executive said, Instead, they asked about “controlling the spend” — the amount of money paid out on certain procedures, he said. Nor would EviCore always use the word “denials” — they employed circumlocutions like “inappropriate determinations.”

Aetna and Cigna are two of the companies that have requested “high touch” plans — those that would send more cases to clinical review and thus generate more denials, according to the former employee involved in data issues.

Aetna did not directly respond to whether it used “high touch” plans. “Although we never automate medical necessity denials, we automate and provide real-time approval of some services to ease administrative burden and allow providers to focus on patient care,” the insurer said in a statement. Cigna did not respond to questions about its use of such plans.

“When you have human eyes on something, you can pick up where there might be a gray area where the algorithm might not pick up,” a former EviCore account executive said. “That is how you would increase the denial rate.”

EviCore can also adjust the algorithm to achieve its internal goals, without the knowledge of clients, former employees said. This happened when EviCore was not generating enough savings to demonstrate its value to insurers, several former employees told ProPublica.

“The pressure from our business leaders was to make sure that we were able to provide evidence of a strong enough impact to justify the contracts with clients,” said the former employee involved with technology.

The system also runs in reverse. When doctors or employer health plans complain about high rejection rates, insurance companies can ask EviCore to back off. The company simply adjusts its algorithm to approve more prior authorization requests.

Dave Jones, a former California insurance commissioner and now director of the climate risk initiative at the University of California, Berkeley School of Law, said arbitrarily increasing or decreasing manual reviews didn’t appear to violate any standards. Still, he questioned whether a payment structure or contract for EviCore based on reducing claims payments or authorizations would result in objective and thorough evaluations of prior authorization requests, as required by law.

“That to me is troubling,” Jones said. “It suggests that the claim settlement procedure is not objective, right?” He added, “It calls into question everything that’s occurring.”

Other industry experts found the manipulation of denial rates upsetting.

“The fact that these big companies focused on profits and can play all these games is quite disturbing to me,” said Martin Lustick, a former insurance executive and the author of a book on industry practices. “They know the more reviews they do, the more denials they get.”

Disputed Guidelines

On March 2, 2022, Cupp and his daughter entered the Adena Regional Medical Center, a gray and glass building surrounded by central Ohio’s low rolling hills.

It had been almost three months since EviCore first turned down coverage for the catheterization. Changing tack, Cupp’s doctor ordered a new exam, which EviCore approved, called a nuclear stress test. It shows how well blood flows through your heart.

A heart catheterization generally costs around $3,500 when done in network, according to Fair Health, a nonprofit that tracks health care prices. A nuclear stress test runs about $315.

Afterward, Cupp greeted Chris in the waiting room. He told her he felt fine. They went for lunch at a favorite hamburger spot. At the time, they did not know the results of the stress test, which showed that his heart was pumping even less blood than indicated by his echocardiogram.

At each step of the way, EviCore had steered Cupp’s medical treatment by denying or approving his doctor’s coverage requests based on its own internal guidelines.

Those guidelines have long been the subject of complaints from doctors. Over the past five years, organizations ranging from the American College of Cardiology to the Society for Vascular Surgery to ASTRO, the American Society for Radiation Oncology, have written to EviCore or regulators that the guidelines are flawed and can interfere with delivering the right care for patients. Benjamin Durkee, a doctor who chairs ASTRO’s payor relations committee, said EviCore had generally made “a good faith” effort to respond to the society’s concerns. But, he noted, the company continues to consistently deny a radiation treatment called proton beam therapy for some pelvic tumors that is more costly but supported by ASTRO’s recommendations.

In a 2019 letter to EviCore, the Society for Vascular Surgery expressed concern about the company’s medical guidelines. Credit:Obtained by ProPublica. Highlighted by ProPublica.

A 2023 academic study examined the criteria EviCore used to approve payment for imaging of the lower spine in cases of extreme pain. It found the guidelines deficient. Two of five medical experts who reviewed the guidelines even recommended not using them.

A 2018 audit by the Centers for Medicare and Medicaid Services, obtained through the Freedom of Information Act, found that Health Care Service Corporation, a Blue Cross Blue Shield insurer, had hired EviCore to review prior authorizations. EviCore, the audit found, played a role in making “inappropriate denials” for 30 patients because it failed to keep its cancer guidelines up to date. As a result, EviCore retrained its staff. HCSC did not respond for comment.

Former employees have also questioned how the guidelines were put to use.

A maternal-fetal medicine physician in Colorado, Gail Miller, took a job as a doctor at EviCore in 2018. The idea of ensuring safe medical practices appealed to her. But she soon grew convinced that EviCore was more interested in saving money.

EviCore rejected her suggestions for improving its maternal fetal health guidelines. Her supervisor required her to decide at least 15 cases an hour — or one every four minutes. She often reviewed requests by physicians outside her specialty.

Nine months after starting at EviCore, Miller quit, disappointed by the attitudes of some of her colleagues. “Most of the physicians who work at these places just don’t care,” she said. “Any empathy they had is gone.”

EviCore noted its clinical staff had “high engagement, satisfaction and retention rates.” It said the most common reason for denying a prior authorization is because doctors neglect to include necessary information.

Results

EviCore meets regularly with insurers and state Medicaid programs. It is a critical part of the business. The company has to demonstrate savings or clients will have little reason to continue their contracts.

Typical was a 2019 meeting with Vermont’s Medicaid program, which for years had used EviCore to review coverage requests for advanced radiology and cardiology scans. A slide show demonstrated how the company had helped lower costs for cardiac imaging through denials. Rates had zigzagged, from a high of almost 15% of requests in one three-month period to a low of 6.1% in another.

But the presentation, obtained through Vermont’s Public Records Act, revealed another way that EviCore saved money for insurers. Prior authorization requests for radiology imaging services had dropped to 3,629, a decline of 16%. Cardiology requests had plummeted even more — down 38% in a little more than a year. Doctors had simply stopped asking for procedures for their patients.

An EviCore executive called this the “sentinel effect” at a legislative hearing in Kansas. It is like the sheriff coming to town. Once doctors know EviCore is watching, they make fewer inappropriate prior authorization requests, he said.

Doctors, however, say that such decreases reflect how difficult it is to fight EviCore and similar companies. Their entrance into the market frustrates doctors from making otherwise legitimate requests.

In its statement, Cigna described the sentinel effect differently. The company said that it helps doctors stay up to date on best practices. “Sentinel effect refers to the reduction in frequency with which physicians order inappropriate services because they are now aware of the latest clinical evidence,” the statement read.

A spokesperson for Vermont’s Medicaid program said the state does not believe that EviCore made unfair or unsound coverage recommendations. Instead, EviCore helped Vermont make “sound decisions from both a fiscal and patient care perspective.”

“It is never a goal for the state of Vermont or our third-party contractors to deny service,” said Alex McCracken, spokesperson of Department of Vermont Health Access. “We are committed to delivery of service for our customers.”

Vermont eventually ended its contract with EviCore because it decided to no longer require prior authorization for advanced imaging scans in its Medicaid program.

“Too Much Say”

The day after his stress test, Cupp drove to his granddaughter’s high school to drop off her archery bow — it had been left behind in the morning rush. He and his wife went shopping at the grocery store. That evening, he watched as his grandkids showed off some baby frogs they had purchased at a pet store.

He went to bed at 8:30 p.m. in order to wake at 2:30 a.m. for the hourlong drive to his job as a maintenance worker at a medical supplies warehouse just south of Columbus.

At about 10:30 p.m., Cupp’s wife, Vivian, shook Chris awake. “Your dad’s breathing funny,” she told her. Chris ran into their bedroom. Her father was gasping for air. Suddenly, he stopped. Chris began CPR. She told her mom to call 911.

By the time the ambulance arrived at Adena Regional Medical Center, where he had received his nuclear stress test 36 hours earlier, his body was mottled and cool. He had suffered cardiac arrest. The time of death was 11:39 p.m.

Chris Cupp, in the home she shared with her family in Bainbridge, Ohio, has been devastated by her father’s death. Credit:Maddie McGarvey for ProPublica

ProPublica asked four cardiology experts to review Cupp’s medical situation. One cardiologist said she would not have recommended a heart catheterization. Given his symptoms, which did not include complaints about chest pain, the best diagnostic tool would have been the stress test, she said.

Three others said the heart catheterization was appropriate. One cardiologist noted that Cupp was diabetic, overweight and showed signs of having suffered a prior heart attack. “It’s very reasonable to say we’ll just go straight to a heart catheterization,” the cardiologist said.

If Cupp had received the procedure when first ordered, his life may have been saved, one expert said. “The doctor was absolutely right to order the catheterization. It was certainly necessary,” said Jonni Cooper, president of American Board of Cardiovascular Medicine and a board certified cardiovascular nurse practitioner.

State and federal regulators rarely impose onerous penalties on companies like EviCore.

Connecticut’s Insurance Department recently reviewed EviCore and Carelon. It found no problems with Carelon. EviCore was fined $16,000 this year for more than 77 violations found in a review of 196 files. EviCore is also accredited by two trade associations, which review companies periodically for compliance with industry standards.

Holding the companies legally responsible for their decisions is also difficult. In 2022, Carelon settled a lawsuit for $13 million that alleged the company, then called AIM, had used a variety of techniques to avoid approving coverage requests. Among them: The company set its fax machines to receive only 5 to 10 pages. When doctors faxed prior authorization requests longer than the limit, company representatives would deny them for failing to have enough documentation. Carelon denied the allegations in court and admitted no fault. A spokesperson declined to comment on the lawsuit.

Elevance, Carelon’s parent company, said its subsidiary “is focused on improving health outcomes while also lowering the cost of care.”

This year, Chris, representing Cupp’s estate, sued United Healthcare, EviCore, the Adena Regional Medical Center and Cupp’s doctor, accusing them of malpractice, among other allegations. Cupp’s attorney, John Markus, later decided to drop United and EviCore. Lawsuits against employer-funded health plans, like the one Cupp had with United, must be tried in federal court, where case law favors insurance companies. For instance, insurers found at fault do not pay punitive damages, only the cost of treatment. The medical center and the doctor declined to comment, citing the ongoing litigation. In court, both denied any wrongdoing. United and EviCore declined to discuss Cupp’s case, despite an offer from Chris to sign a waiver of medical privacy rights.

Her father’s death wracked Chris. He had been her best friend. He helped raise her three kids. He provided for the family. Two years before his death, he purchased a new double-wide trailer to replace a rusting single-wide the family had lived in for years. It had four bedrooms, enough for everyone. It stood on the side of a hill, surrounded by oak and maple, a leafy retreat with a view of the valley below.

Cupp was buried at a cemetery across from a cornfield on March 9. A gray granite headstone marks his date of death.

Chris Cupp drives a school bus to make ends meet. For extra pay, she picks up a lot of the trips for night games. She says she hopes that no one else has to go through what she did.

“Insurance has too much say over something that can save your life,” she said. “When it comes to your heart, something that’s going to kill you, they have too much say in that. That’s my thought about it.”

I spent nearly 20 years with some responsibility for managing care for more than just my patients – I worked as a medical director with liaison responsibilities for as many as 100,000 patients.  That meant different things at different times, but it all had to do with ensuring that the patients got the best care for the least amount of money.  For me, the priority was on the best care, but if you know me, you know I see the waste in the system.  Over the past decades now there has been a strong focus on decreasing cost, and from my perspective, resulting in “the hell with the patient”.  Ok, that might be overstated, but if you’re the individual, you could easily be screwed.   

Years ago a patient with migraines was prescribed botox when it was still largely experimental.  The insurance company at the time reviewed the case, the specific patient history, and approved a trial.  When the treatment worked, it was ultimately approved going forward.  The patient’s employer changed insurances, and the process started up again.  This time, despite a long history of successful treatment, and the fact that the FDA approved botox for migraines, and that the Neurological Society came out in favor of including botox as a regular therapy, the insurance company denied the service.  And the patient went back to being miserable until they could pay out of pocket for the only therapy that had worked.  

Source: https://www.propublica.org/article/evicore...

Even a little exercise can really change your life's trajectory

One day you go to the doctor and he says “you have diabetes”, as if you just got it.  WRONG!  You’ve been working on it for years – many, many years.  Your sugar ever so slowly starts to climb (your body can’t keep up) until it reaches the level that your regular doctor finally tells you’ve hit the dreaded “D”-level.  But as you’ve heard, exercise can make a huge difference – but how much of a difference?  

This study, while small, has profound implications.  Hang in there while I try to explain it – it’s a little complicated if you are unfamiliar with the particulars.  Some definitions first.

Think of an oral glucose tolerance test (OGGT) as drinking a sickeningly sweet drink all at once, then checking blood sugar levels an hour and two later.  Insulin sensitivity is how relatively self-explanatory – how sensitive your body is to insulin (hint – it should be really sensitive), and type 2 diabetes is all about insulin insensitivity (also known as glucose intolerance).  

The study takes young (average age 35) people who are sedentary or moderately active, normal to slightly overweight, with no evidence of diabetes and tests them with OGGTs.  First, they’re asked to sit around for 4 days and then they’re tested, giving us some blood sugar and insulin levels.  They are then asked to do an easy jog for 30 minutes and are tested again on the following day.  

The findings are profound – a significant drop in blood sugars and insulin levels after the simple jog.  That’s after 1 jog!  What if someone actually did REGULAR exercise!!!  

Research studies have shown that a full 25% of normal, skinny, healthy, active youth (college age) already show evidence of being on the way to diabetes.  I’m sure some of these subjects were among the group that would have qualified, but if we can’t know who’s at risk, and we have an opportunity to seriously impede progress to a life-threatening condition, why wouldn’t we take advantage!?!  

But hey, here I am talking about exercise again.  Go figure.

A Single Jog Can Improve Glucose Metabolism in Young Adults

TOPLINE:

In healthy young adults, a single 30-minute bout of outdoor aerobic exercise significantly reduces fasting and 1-hour glucose levels during an oral glucose tolerance test (OGTT) the next day and improves insulin sensitivity.

METHODOLOGY:

  • Recent studies have identified 1-hour post-load glucose concentration during an OGTT as a specific and early predictor of diabetes, and exercise has long been known for its metabolic benefits in people with and without diabetes.

  • The researchers investigated the effect of a single bout of aerobic exercise on 1-hour post-load glucose levels during an OGTT in 32 young, healthy, normal-weight or marginally overweight individuals (mean age, 35 years; 14 women and 18 men) with a sedentary or moderately active lifestyle.

  • The participants underwent an initial OGTT after at least 4 days of physical inactivity, followed by a second OGTT the day after a single 30-minute bout of aerobic exercise.

  • The exercise session consisted of a light jog for 30 minutes, monitored using a metabolic holter to quantify energy expenditure and exercise intensity. The participants did not undertake any exercise outside the lab sessions.

  • Blood glucose levels were measured, and insulin sensitivity and secretion were estimated using surrogate indices derived from OGTT glucose and insulin assays, including the Matsuda index, oral glucose insulin sensitivity (OGIS) index, and quantitative insulin sensitivity check index, as well as the homeostasis model assessment (HOMA) of insulin resistance and of beta-cell function (HOMA-B).

TAKEAWAY:

  • A single 30-minute bout of aerobic exercise significantly reduced 1-hour post-load glucose levels from 122.8 mg/dL at baseline to 111.8 mg/dL ( = .03) the day after exercise.

  • Postexercise insulin levels also were significantly lower 1 hour after glucose load, decreasing from 57.4 IU/mL at baseline to 43.5 IU/mL the day after exercise ( P = .01).

  • Insulin sensitivity improved significantly after exercise, as indicated by increases in the Matsuda index ( = .02) and OGIS index ( = .04), along with a reduction in insulin resistance ( = .04).

  • The study found a trend toward increased beta-cell function the day after an exercise bout, as indicated by a nonsignificant increase in HOMA-B from 144.7 at baseline to 167.1 after exercise.

IN PRACTICE:

“Improvement in 1-hour post-load plasma glucose following a single session of aerobic physical activity suggests that exercise could have a direct effect on T2D [type 2 diabetes] risk and cardiovascular risk,” the authors wrote.

SOURCE:

The study was led by Simona Moffa, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, and Gian Pio Sorice, University of Bari "Aldo Moro," Bari, Italy. It was published online in the Journal of Endocrinological Investigation .

Source: https://www.medscape.com/viewarticle/singl...

Not when you eat, but HOW LONG you're eating makes a difference - and quickly!

I believe that everyone should NOT EAT for MORE THAN 12 hours a day.  There are lots of variations under the topic – TIME RESTRICTED EATING.  There’s been some data about making your eating window early in the day is better than later in the day, and that it might be better for weight loss.  While that’s interesting, this study shows that didn’t make a difference.  

What it did show, and what’s frankly more important, is that, even after only 3 days there’s a clear improvement in blood sugar levels when you restrict your eating to 8 hours a day.  None of the subjects had frank diabetes, but were all at substantial risk that they were heading that way.  As such, any improvement in sugar levels would translate into, at the least, a delay in frank diabetes, but might have greater effects to keep patients from actually becoming diabetic at all.  

Please let me know if you have any questions – a phone call might be really clarifying!

Early vs Late Fast Window: Is One More Effective?

A daily 8-hour eating window controls blood glucose whether followed early or late in the day by people at risk for type 2 diabetes, showed a time-restricted eating (TRE) study presented at the European Association for the Study of Diabetes (EASD) 2024 Annual Meeting.

The study, examining shifting the time of day for the 8-hour eating window along with a tightly controlled diet, found that 8 hours of TRE — whether early or late in the day — led to a significant improvement in the time spent within a normal daily blood glucose range and in glycemic variability.

"We didn't show a benefit in terms of early versus late TRE, but we did show a benefit of time-restricted eating within a window of 8 hours per day," said study lead Kelly Bowden Davies, MSc, PhD, from Manchester Metropolitan University, Manchester, England, when presenting the work. "It doesn't matter when you restrict eating, but if you restrict it to 8 hours then, according to our study, it benefits glycemic control in people at risk of type 2 diabetes."

The researcher added that the effect was seen after only 3 days, and "demonstrates its therapeutic role in adults at risk of type 2 diabetes, which warrants investigation in the longer term."

The current study examined the effect of shifting the time of day for the TRE window from early (8 am-4 pm) to late (12:00 pm-8 pm) in people at risk of developing type 2 diabetes due to a lifestyle characterized as sedentary and poor diet.

Previous studies indicate that TRE, which limits when, but not what, individuals eat, can improve insulin sensitivity and A1c in people at risk for type 2 diabetes.

But Bowden Davies pointed out that the effect of TRE on glycemic variability remained unclear. While prior work had attributed the positive effects of TRE to reduced energy intake, this study provided a diet where energy consumption matched energy expenditure — taking into account sex, age, weight, height, and activity level, termed a "eucaloric" diet.

"Some research groups recognize that if we manipulate the time at which we eat, then we can better align with circadian metabolic rhythms to improve whole body insulin sensitivity and glycemic variability," explained Bowden Davies. "It may be that eating in the morning may be better aligned [with circadian rhythms] and cause greater improvement in glucose control."

Three-day TRE plan led to blood glucose control

In a cross-over study design, all 15 participants were randomized to follow the early and late TRE regimens with a 7-day washout period in the middle. Participants had a mean body mass index (BMI) of 27.7 kg/m2, a mean waist circumference of 73 cm, were sedentary, and followed a poor diet.

"Participants were normoglycemic so had good glucose control, but due to having overweight and obesity, they are considered as having risk factors for the development of type 2 diabetes," noted Bowden Davies.

Before the TRE period, participants provided researchers with a dietary record. If they started on the early TRE, they crossed over to the late TRE after the washout period, and vice versa, she explained.

Continuous glucose monitoring (FreeStyle Libre 2, Abbott Laboratories) was carried out across the study to assess the daily time spent in euglycemia (3.9-7.8 mmol/L) and provide markers of glycemic variability, including mean absolute glucose, coefficient of variation, and mean amplitude of glucose excursions. Blood draws both pre- and post-TRE period provided biochemical measurements, and anthropometric readings were also taken.

There were nine female participants, with a mean age of 52 years, a BMI of 28 kg/m2, and an A1c level of 37.9 mmol/mol (5.6%). They tended to snack across an eating period of 14 hours per day or more (habitual eating). They were assigned to two different investigational eating patterns for 3-day durations: Early or late, and these findings were compared with those from participants who continued their habitual eating.

Participants were provided with a eucaloric, standardized diet [50% carbohydrates, 30% fat, and 20% protein] to be eaten during the TRE period, whereas they ate as usual (ie, as and what they wanted) when not on the TRE regimen.

No changes were seen in the biochemistry markers assessed. "Given they only followed the TRE for 3 days, this is unsurprising," remarked Bowden Davies. "We did see weight loss after only 3 days of TRE of around 1.1 kg across the two interventions," she reported.

Referring to the early vs late TRE regimen, she added that "we didn't see a benefit [no significant differences in glycemic control] of early compared with late TRE, but we did see a benefit of restricting the eating window to 8 hours per day, so both conditions [early and late TRE regimens] had a benefit on glucose control."

Variables of blood glucose control were also reduced while on the TRE regimen compared with habitual eating (more than 14 h/d), with significantly increased time spent within the normal blood glucose range on average by 3.3%, and also reduced mean absolute glucose by 0.6 mmol/L, coefficient of variation by 2.6%, and mean amplitude of glucose excursions by 0.4 mmol/L.

"Within 3 days, this is quite striking," Bowden Davies pointed out.

She added that these data were interim analyses, but "these are positive in terms of participants seeing a benefit in glucose control and glycemic variability, which is a risk factor for developing type 2 diabetes but also for microvascular complications. We also saw improved time in range in terms of tight glucose control."

"Even in 3 days, there were small, subtle differences which are subclinical — but this is not a clinical cohort. The results are statistically significant and a promising piece of data to suggest a feasible intervention that could be translated across different populations," she said, adding that over a longer time period, changes between TRE timing might show changes in people at risk for type 2 diabetes who don't have compromised circadian rhythms.

Moderating the session was Lutgarda Bozzetto, MD, from the University of Naples Federico II, Naples, Italy. She told Medscape Medical News, "It's a hot topic right now, and the finding that there's no difference in the time of day when the restricted eating is done suggests that in people at risk of diabetes, the hormonal flux and cycle involved in blood glucose control is not so strong or sensitive."

Using a continuous glucose monitor, they can look at their blood glucose levels after eating, and this might "be powerful in guiding behavioral change," said Bozzetto.

Source: https://www.medscape.com/viewarticle/early...

Stay out of the Hospital? GET OFF THE COUCH!

I probably sound like a broken record (does anyone know what that reference even means?) – EXERCISE is THE MOST POWERFUL intervention available for your health.  And here’s another article that supports that.  A group of older patients (oh my, I might actually be in this group?!?) with average age of 69 ½ years, but mostly women, were entered into a private gym supervised exercise program and that yielded hospitalization rates at only ½ of those who didn’t exercise!  They only saw a significant difference in women (there probably weren’t enough men to show the statistical difference), and the population was hardly committed to the long term, but even with that, the women crushed it.  It’s not the best study (some clear potential confounders), but heck, I’m piling on when it comes to the need for exercise!  Let’s get moving!

FROM AJPM / BY Donald S. Wright, MD, MHS, Bin Zhou, MS, Catherine X. Wright, MD, Robert S. Axtell, PhD, Abeel Mangi, MD, Basmah Safdar, MD, MSc

Association Between Exercise Program Participation and Hospitalization of Older Adults

Abstract

Introduction

Government and insurance sponsored exercise programs have demonstrated decreased hospitalizations, but it is unclear if this is the case for self-referred programs.

Methods

In this retrospective cohort study from 2013 to 2020, older adults who participated for at least three months at a community-based exercise center (participants) were compared with those who did not (nonparticipants). Each completed a baseline physical assessment and periodic reassessments thereafter. These data were paired with regional hospital data and a national mortality database. Statistical analysis and modeling were performed from 2020 to 2023. Survival to all-cause hospitalization was assessed with a priori subgroup comparison by gender and cox proportional hazard modeling by age, gender, and comorbidities.

Results

The cohort included 718 adults, mean age 69.5 years (SD 8.4), with 411 (57.2%) participants and 307 nonparticipants. Mean follow-up was 26.7 months. Participants had similar baseline measures of fitness (p>0.05) but were more likely to be retired and less likely to have diabetes or prior stroke than nonparticipants. Sustained participation was associated with a reduced rate of all-cause hospitalization (9.0% vs. 12.7%, p=0.02), even when adjusted (HR 0.54; 95% CI 0.34, 0.87, p=0.01). This decrease was noted only in women (p=0.03) but not in men (p=0.49), gender was nonsignificant after adjustment for comorbidities (p=0.15).

Conclusions

Exercise program participation was independently associated with decreased risk of all-cause hospitalization, with possible differential effects by gender. Further randomized trials of the benefits of personalized exercise programs are warranted to assess sex- and gender-specific effects.

Source: https://www.ajpmonline.org/article/S0749-3...

Ozempic / Mounjaro can be hard on your body -- help it out

GLP-1s (Mounjaro, Ozempic, Zepbound, Wegovy) can be really helpful with weight loss.  It improves how your body uses sugar, helps burn fat and can translate into rapid weight loss in some people.  However, it slows the gut down tremendously, can increase nausea dramatically and effects many people severely enough to cause more than half of them to not finish a course of therapy.  For the people who do tolerate it and it works, they have significant metabolic risks because it works.  

Big weight loss means losing a bunch of fat, but it often comes with protein or lean body mass.  Also, bone density can drop, vitamins can be missing and constipation can be severe.  The article describes advice from one doc who’s seen lots of these weight loss folks and gives some good information for everyone. 


Five Essential Nutrients for Patients on GLP-1s

Fatigue, nausea, acid reflux, muscle loss, and the dreaded "Ozempic face" are side effects from using glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) such as semaglutide or the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RA tirzepatide to control blood sugar and promote weight loss. 

But what I've learned from working with hundreds of patients on these medications, and others, is that most (if not all) of these side effects can be minimized by ensuring proper nutrition. 

Setting patients up for success requires dietary education and counseling, along with regular monitoring to determine any nutritional deficiencies. Although adequate intake of all the macro and micronutrients is obviously important, there are five nutrients in particular that clinicians should emphasize with their patients on GLP-1 RAs or GIP/GLP-1 RSs. 

Protein

My patients are probably sick of hearing me talk about protein, but without the constant reinforcement, many of them wouldn't consume enough of this macronutrient to maintain their baseline lean body mass. The recommended dietary allowance (RDA) for protein (0.8 g/kg bodyweight) doesn't cut it, especially for older, obese patients, who need closer to 1.0-1.2 g/kg bodyweight to maintain their muscle mass. For example, for a 250-lb patient, I would recommend 114-136g protein per day. This is equivalent to roughly 15 oz of cooked animal protein. It's important to note, though, that individuals with kidney disease must limit their protein intake to 0.6-0.8 g/kg bodyweight per day, to avoid overtaxing their kidneys. In this situation, the benefit of increased protein intake does not outweigh the risk of harming the kidneys.

It's often challenging for patients with suppressed appetites to even think about eating a large hunk of meat or fish, let alone consume it. Plus, eating more than 3-4 oz of protein in one meal can make some patients extremely uncomfortable, owing to the medication's effect on gastric emptying. This means that daily protein intake must be spread out over multiple mini-meals. 

For patients who need more than 100 g of protein per day, protein powders and premade protein shakes can provide 20-30 g protein to fill in the gaps. Although I always try to promote food first, protein supplements have been game changers for my patients, especially those who find solid food less appealing on the medication, or those who avoid animal protein. 

Clinicians should have their patients monitor changes in their lean body mass using a dual-energy x-ray absorptiometry scan or a bioelectrical impedance scale; this can be a helpful tool in assessing whether protein intake is sufficient. 

Fiber

Even my most knowledgeable and compliant patients will experience some constipation. Generally speaking, when you eat less, you will have fewer bowel movements. Combine that with delayed gastric emptying and reduced fiber intake, and you have a perfect storm. Many patients are simply not able to get in the recommended 25-35 g fiber per day through food, because fibrous foods are filling. If they are prioritizing the protein in their meal, they will not have enough room for all the vegetables on their plate. 

To ensure that patients are getting sufficient fiber, clinicians should push consumption of certain vegetables and fruits, such as carrots, broccoli, brussels sprouts, raspberries, blackberries, and apples, as well as beans and legumes. (Salads are great, but greens like spinach are not as fibrous as one might think.) If the fruit and veggie intake isn't up to par, a fiber supplement such as psyllium husk can provide an effective boost.

Vitamin B12

Use of these medications is associated with a reduction in vitamin B12 levels, in part because delayed gastric emptying may affect B12 absorption. Low dietary intake of B12 while on the medications can also be to blame, though. The best food sources are animal proteins, so if possible, patients should prioritize having fish, lean meat, eggs, and dairy daily. 

Vegetarians and vegans, who are at an increased risk for deficiency, can incorporate nutritional yeast, an excellent source of vitamin B12, into their daily routine. It is beneficial for patients to get bloodwork periodically to check on B12 status, because insufficient B12 can contribute to the fatigue patients experience while on the medication.

Calcium

Individuals should have calcium on their radar, because weight loss is associated with a decrease in bone mineral density. Adequate intake of the mineral is crucial for optimal bone health, particularly among postmenopausal women and those who are at risk of developing osteoporosis. The RDA for calcium is 1000-1200 mg/d, which an estimated 50% of obese individuals do not take in

Although dairy products are well-known for being rich in calcium, there are other great sources. Dark green leafy vegetables, such as cooked collard greens and spinach, provide nearly 300 mg per cup. Tofu and sardines are also calcium powerhouses. Despite the plethora of calcium-rich foods, however, some patients may need a calcium supplement.

Vitamin D

Vitamin D deficiency or insufficiency is common among individuals with obesity, so even before these patients start the medications, supplementation may be warranted. The vitamin's role in promoting calcium absorption, as well as in bone remodeling, make adequate intake essential for patients experiencing significant weight loss.

Clinicians should emphasize regular consumption of fatty fish, such as salmon, as well as eggs, mushrooms, and vitamin D–fortified milks. But unfortunately, that's where the list of vitamin D–rich foods ends, so taking a vitamin D supplement will be necessary for many patients.

Regularly monitoring patients on GLP-1 RAs through bloodwork to check vitamin levels and body composition analysis can be helpful in assessing nutritional status while losing weight. Clinicians can also encourage their patients to work with a registered dietitian who is familiar with these medications, so they can develop optimal eating habits throughout their health journey. 

Source: https://www.medscape.com/viewarticle/five-...

76 Breast Cancer Linked Chemicals found in Food Packaging -- and in People!

It should come as no surprise – today, everyone is TOXIC, and I don’t mean they give off bad energy.  I mean that our bodies are all exposed to things that we don’t want IN our bodies.  Back in the day, people talked about leaded gasoline and paint.  So lead was taken out of gas and paint.  But interestingly, jet fuel is still leaded and exhausts continue to spew lead into the atmosphere. 

What people don’t talk about is what happened to all that lead?  Obviously, lead is heavy.  It falls (out of the sky from planes), but it used to spew out of car exhausts.  Where did it all go?

Mostly, it dropped to the pavement, or was aerosolized and carried short distances to land on some property.  And then it drained into the soil, or perhaps the water supply.  Ultimately, it ends up in the food supply, amongst other places.  Point being that it can end up in us.  

There are now over 30,000 chemicals that have been created that are “new to nature”.  The vast majority of them have not been tested for safety.  The government actually has a certification known as GRAS that specifically states it has not been tested for safety (GRAS stands for Generally Regarded as Safe – an extrapolation from some similar products previously evaluated).  Lots and lots of “stuff” gets into the environment and years later someone figures out it not good for us.   

The CNN report (don’t get political – it’s health news!) summarizes a toxicology paper that describes how food packaging materials have been demonstrated to leak into foods they are holding.  And a number of those chemicals end up in the humans that eat the food.  BPA was one of the chemicals that only relatively recently was declared as a bad actor and mostly removed from packaging (think baby bottles in the microwave!! Yikes).

These kinds of toxicities drive all kinds of health issues.  Understanding your level of personal toxic burden can be very helpful in avoiding future disasters.  Understanding your personal genetic tendencies in how well you are able to clear these toxins is another important piece of the puzzle to potentially keeping out of the TOXIC SOUP that may all await us if we keep on our current path.  

If any of these things concern you, please, let’s have a conversation.

FROM CNN HEALTH / BY SANDEE LAMOTTE

Chemicals linked to breast cancer leach into our foods, study finds

Nearly 200 chemicals connected to breast cancer are used in the making of food packaging and plastic tableware, and dozens of those carcinogens can migrate into the human body, a new study found.

“There is strong evidence that 76 known or potential breast carcinogens from food contact materials recently purchased all over the world can be found in people,” said study coauthor Jane Muncke, managing director and chief scientific officer at the Food Packaging Forum, a nonprofit foundation based in Zurich, Switzerland, that focuses on science communication and research.

“Getting rid of these known or suspected carcinogens in our food supply is a huge opportunity for cancer prevention,” Muncke said.

Of the recently detected chemicals in food packaging, 40 are already classified as hazardous by regulatory agencies around the world, according to the study.

“So many of these chemicals have already been classified as human health hazards, yet they are still allowed to be used in food contact materials, thus allowing them to migrate into the food we eat,” said Jenny Kay, a research scientist at Silent Spring Institute, a scientific research organization focused on the link between chemicals, women’s health and breast cancer. She was not involved in the study.

Rates of early-onset breast cancer in women under 50 are increasing, and experts said the trend cannot be explained by genetics alone.

Rates of colon cancer are also rising in younger people,” said Dr. Len Lichtenfeld, former deputy chief medical officer for the American Cancer Society who was not involved in the study.

“Is it obesity? Is it alcohol? Is it the lack of physical activity? Is it environmental? There are a lot of reasons,” Lichtenfeld said, “and it’s going to take a long time to sort which has the most impact, as some of these chemicals may be high risk, some low risk.”

The Consumer Brands Association, which represents the consumer products industry, told CNN that its members adhere to the US Food and Drug Administration’s evidence-based safety standards.

“Packaging exists to protect and keep food safe for consumption,” said Sarah Gallo, the association’s senior vice president of product policy and federal affairs, in an email.

“The FDA reviews and approves food contact substances through their science and risk-based system before they go to market,” Gallo said. “The agency’s post market review also provides continuous safety analysis and regulation of the approved substances.”

The FDA has been under fire for its failure to act quickly on health concerns about some 14,000 chemicals known to be added to food. The agency will hold a public meeting Wednesday to present its ideas on how to improve its post-market food analyses.

Possible breast carcinogens

In 2007, Silent Spring published a list of 216 chemicals that can cause mammary tumors in rodents — a key method for determining toxicity, according to experts.

A January 2024 update to that list found 921 possibly carcinogenic chemicals, including 642 that may stimulate estrogen or progesterone production, another known risk factor for breast cancer.

“The fact that so many potential breast carcinogens are present in food packaging and can migrate into our food is just one example of how many chemicals we are unwittingly exposed to every day,” said Kay, who coauthored the 2024 study update published in Environmental Health Perspectives.

“Many of the mammary carcinogens are hormone disruptors, too, and many of the chemicals on our list can also damage DNA,” she said. “Consumers should not have to keep track of all of the scientific literature on what chemicals to avoid. It should be on regulators to recognize the danger and take action.”

Carcinogens in plastic, paper and cardboard

The new study, published Tuesday in the journal Frontiers in Toxicology, compared the Silent Springs database of known carcinogens for breast cancer with the Database on Food Contact Chemicals Monitored in Humans, or FCChumon.

FCChumon, created by the Food Packaging Forum, is a list of food contact chemicals that have been detected in human breast milk, blood, urine and tissues.

“The new study took our list of potential breast carcinogens and compared it to their list of chemicals that have been found in food contact materials to find out which of potential breast carcinogens could be getting into people’s diets,” Kay said. “That’s a great way to prioritize chemicals for regulatory action.”

The study found such chemicals as benzene, a known carcinogen connected to breast cancers in animals and people; 4,4’-Methylenebis-(2-Chloroaniline), a probable carcinogen linked to bladder cancer; 2,4-Toluenediamine, found to cause breast and other cancers in animals; and 3,3′-Dimethylbenzidine and o-Toluidine, which are dyes used to color plastic and paper.

“Dyes can be used in plastics, paper, cardboard and the like and can have some pretty toxic properties,” Kay said. “Plastics are not the only culprit.”

In fact, while the study found most of the exposure to carcinogens came from plastics used in food packaging, 89 suspected carcinogens were found in paper and cardboard containers.

“Paper has additives such as emulsifiers and adhesives, say if papers are glued together, or there’s a plastic layer glued to the paper,” Muncke said.

PFAS, phthalates and other worrisome chemicals are used to make plastic soft and flexible and to produce grease-proof food containers.

A number of the chemicals found in the study were bisphenols, phthalates or perfluoroalkyl and polyfluoroalkyl substances, known as PFAS — worrisome chemicals that have been linked to many health concerns.

Often called “forever chemicals” because they do not break down in the environment, PFAS are used in food packaging to prevent grease and water from soaking through food wrappers and beverage cups. PFAS can also be found in the ink used to print logos and instructions on food containers.

Chemicals in the PFAS family are linked to high cholesterol, cancer and various chronic diseases as well as a limited antibody response to vaccines in both adults and children, according to a report by the National Academies of Sciences, Engineering, and Medicine.

Phthalates have been linked to childhood obesityasthmacardiovascular issues, cancer and premature death in people ages 55 to 64.

Bisphenol A, or BPA, is an endocrine disruptor that has been linked to fetal abnormalities, low birth weight, and brain and behavior disorders in infants and children. In adults, the chemical has been linked to the development of diabetes, heart diseaseerectile dysfunctioncancer and a 49% higher risk of early death within 10 years.

Steps to take to reduce exposure

While it’s up to regulatory agencies to make sweeping changes to protect the food supply, there are steps consumers can take to reduce the risk of toxic chemicals and carcinogens, according to Silent Spring.

Source: https://www.cnn.com/2024/09/24/health/brea...

To Live Longer, Get to Know Your Toes

I mentioned sometime in the past a study that tied standing on one leg to mortality risk.  The same guy has worked out more details around flexibility and mortality.  Over 13 years, the difference between being pretty flexible and not being flexible is translated into a difference from 1% up to 18-26%!! That’s a crazy difference, but, as usual, you really need to parse this result.  They plainly admit that they didn’t stratify people with regards to activity or lifestyle going into the study, so it might be that the less flexible group was already sicker and that contributed to the difference.  The difference varied by gender –flexible vs less flexible translated into a doubling of mortality for men, a 5-fold increase for women.  

What this doesn’t tell us is whether or not stretching regimens will help these statistics, but it’s clear other aspects of this kind of thing does make a difference – balance training, strength training, etc all translate to better outcomes.  It mostly follows (though not a given) that stretching would be beneficial, if not for mortality, at least for quality of life.  

An easy way to start is with sun salutations – a cornerstone of yoga.  A great, comprehensive review of how to start is here: https://www.youtube.com/watch?v=L4Z7lix6Qao&ab_channel=YouAligned

Get STRETCHING!

The more flexible you are as you age, the longer you're likely to live.

That's the conclusion of a new study that associated increased flexibility in middle age with a lower odds of mortality over the next dozen or so years.

The prospective cohort study, which evaluated the flexibility of more than 3100 men and women in Brazil, found body flexibility was strongly and inversely associated with mortality risk over a 13-year follow-up period.

Claudio Gil Araújo, MD, PhD, the research director of the Exercise Medicine Clinic-CLINIMEX in Rio de Janeiro, who led the study, said his group was not surprised by the results. "We found what we expected. Reduced flexibility was related to poor survival," he said.

The findings, published today in the Scandinavian Journal of Medicine & Science in Sports, used data from 2087 men and 1052 women who underwent a medical-functional evaluation at CLINIMEX. They received a body flexibility score, called the Flexindex, based on range of motion in 20 movements in seven joints, with a minimum score of 0 and a maximum score of 80.

Among the 3139 participants, there were 302 deaths (9.6%) during a mean follow-up of 12.9 years with cardiovascular diseases and cancer the most common underlying causes in men and women, respectively.

"The probability of death during nearly 13 years of follow-up was close to 1% when Flexindex scores exceed 49 for men and 56 for women," Araújo told Medscape Medical News. "On the other hand, for men and women placed in the lower 10th percent of Flexindex scores, death rates were, respectively, 26.9% and 18.2%."

Barry Franklin, PhD, director of preventive cardiology and cardiac rehabilitation at Corewell Health William Beaumont University Hospital in Royal Oak, Michigan, and a co-author of the new study, said men with the poorest flexibility were nearly twice as likely to die over the follow-up period than men with high flexibility. Women with the poorest flexibility were almost five times more likely to die than those with high flexibility.

Flexibility Assessment and Training

Araújo opened CLINIMEX in 1994, and since then, its staff of five physicians have evaluated more than 10,000 individuals using the Flexitest. Araújo has published two previous studies on flexibility. The first showed that the ability to rise from a sitting position on the floor is a strong predictor of longevity, and the second demonstrated that the inability to stand on one leg for at least 10 seconds is linked to an increased risk for death over 7 years.

Araújo and his colleagues believe the current study is the first to assess the association between levels of body flexibility and mortality. But the observational analysis was unable to establish causality, and therefore, they could not show a definitive mechanism to explain the association between low levels of flexibility and premature mortality.

The authors noted several limitations of their study. The participants were primarily affluent Whites, and the researchers did not control for the time of day flexibility was measured or for variables such as diet and physical activity. They also acknowledged reduced flexibility may be a consequence of poor lifestyle habits rather than a causal risk factor for mortality.

Jonathan Bonnet, MD, MPH, an exercise expert at the Stanford Center on Longevity Lifestyle Medicine in California, said the researchers used a more robust evaluation of flexibility than a traditional sit-and-reach test. However, he expressed concern that the primary comparisons were of the upper and lower 10% of performers and that the average differences in Flexindex scores between people who died and those who survived were only a handful of points in an 80-point test.

"People who are not flexible probably have other health-related issues that limit their mobility and those who are very flexible are either genetically different from inflexible individuals or are doing something to maintain or increase their flexibility to a high level," Bonnet said. "Not knowing how active or inactive people are at baseline when flexibility was assessed or over the duration of the study limits how confident we can be that flexibility is the cause of mortality."

Bonnet, a member of the American College of Lifestyle Medicine, noted that the latest guidelines on physical activity from the US Department of Health and Human Services do not include recommendations on stretching, given the lack of data demonstrating its specific health benefits. While maintaining mobility and range of motion in joints is important for long-term health, he said the new study does not provide sufficient evidence to recommend stretching as a way to reduce mortality.

"Until there are more data that can show a cause-and-effect relationship with stretching and health outcomes, time is better spent doing aerobic and muscle-strengthening activities," Bonnet said.

Franklin said future studies could better account for missing potential confounders like physical activity and whether individuals were taking protective medications, such as aspirin, cholesterol-lowering drugs, or beta-blockers. Studies also are needed to assess whether training-induced gains in flexibility are specifically related to increases in survival and whether their findings apply to people over the age of 65, he said.

The current findings "give us some additional ammo to say, 'Wow, being more flexible may, in fact, improve long-term survival or outcomes'," Franklin said. Regardless, flexibility still "improves quality of life, it improves balance and reduces the potential for falls, and all those things make it worthy of better recognition or appreciation by the general public and clinicians," he added.

Araújo said he would like his research to influence people's health. "While to exercise regularly is advisable, what really matters is to be physically fit and not only in aerobic or strength fitness but also in flexibility," he said. "The study is adding a new and, I believe, important 'relevant for survival' label on flexibility assessment and training."

Recommended Stretches for Increased Mobility and Flexibility

Matthew Accetta, MS, exercise physiologist at Hospital for Special Surgery in New York City

Matthew Accetta, MS

Hip Hug Stretch

This stretch effectively targets the gluteal muscles, piriformis, and other deep hip rotators, which can become tight from prolonged sitting or lack of movement. Tight hips can contribute to lower back pain. By stretching the hip muscles, you can reduce tension and pressure on the lower back. Regularly performing this stretch helps to improve hip joint mobility, which is essential for maintaining functional movement and preventing stiffness as you age.

  • Start by sitting and crossing one leg over the other.

  • Hug your knee to your chest.

  • Focus on keeping your chest up to feel the stretch in the glute.

  • Hold for 20-30 seconds.

  • Repeat on the opposite side.

Half Kneeling Hip Flexor Stretch

As people age, they often spend more time sitting, which can lead to tight hip flexors. This stretch specifically targets these muscles, helping to alleviate tightness and improve mobility. Tight hip flexors can contribute to poor posture by pulling the pelvis into an anterior tilt, which can lead to lower back pain and other postural issues. Stretching these muscles helps to counteract this effect and promote better posture.

  • Kneel on a pad (the side you kneel on is the side being stretched); position the front leg far enough away so the front knee stays behind the toes.

  • With a tall posture, engage your abdominals and tuck your tailbone by engaging your glutes until a stretch is felt in the front of the thigh on the kneeling leg.

  • Hold for 20-30 seconds.

  • Repeat on the opposite side.

Calf Stretch at a Wall

Tight calf muscles can lead to discomfort and limit the range of motion in the ankles. Stretching the calves helps to maintain and improve flexibility in these muscles. Flexible calf muscles contribute to better mobility in the ankles and feet, making daily activities like walking, climbing stairs, and running more comfortable. Tight calves can increase the risk for strains, Achilles tendonitis, and other injuries. Stand facing a wall with your hands on the wall at about eye level. Put the leg you want to stretch about a step behind your other leg.

  • Stand in a staggered stance in front of a wall with your arms stretched out.

  • Keeping your back heel on the floor, bend your front knee until you feel a stretch in the back leg.

  • Hold the stretch for 15-30 seconds.

  • Repeat on the opposite side.

Standing Quad Stretch

Regularly stretching the quadriceps helps maintain and improve flexibility in these muscles, which is crucial for overall lower body mobility. Flexible quadriceps are less prone to strains and injuries. Tight quadriceps can contribute to knee pain and discomfort by exerting excessive pressure on the knee joint. Stretching these muscles helps alleviate this pressure and reduce knee pain.

  • While standing, hold onto a countertop or chair back to assist in balance.

  • Bend your knee by grasping your ankle with one hand and moving your foot toward your buttocks.

  • Gently pull on your ankle to bend your knee as far as possible.

  • Maintain the position for 30 seconds.

  • Repeat on the opposite side.

Seated Hamstring Stretch

Regularly stretching the hamstrings helps maintain and improve their flexibility, which is crucial for the overall mobility of the lower body. Tight hamstrings can contribute to lower back pain by pulling on the pelvis and causing an anterior pelvic tilt. Stretching these muscles can help alleviate tension and reduce back pain. Hamstring flexibility helps to contribute to a better range of motion in the hip and knee joints, making daily activities such as walking, bending, and reaching easier.

  • Sit on the front half of a firm chair with your back straight.

  • Extend one leg out in front of you with your heel on the floor and your toes pointed up.

  • Bend the opposite knee so that your foot is flat on the floor.

  • Center your chest over your straight leg.

  • Slowly lean forward at the hips until you feel a stretch in the back of your thigh.

  • Hold the stretch for 30 seconds.

  • Slowly return to your original position and repeat on the opposite side.

Source: https://www.medscape.com/viewarticle/live-...

Does Time Restricted Eating (some call it Intermittent Fasting) result in weight loss?

In recent months the excitement about fasting has died down a bit, but there’s lots of interesting data surrounding it’s utility.  Most of the excitement centered around, you guessed it – the possibility that it would drive weight loss.

We’ve talked about this a bit in the past – it’s important to get the terminology right.  Many/most Americans fail to get a full 12 hour fast overnight.  To me, that’s an absolute necessity – you’ve got to NOT eat for more time than you DO eat (if you eat late - 8 or 10pm, then you shouldn’t eat again until the earliest at 8 am or 10 am, respectively).  Time Restricted Eating (TRE) is when you restrict your eating window to shorter than 10 hours, all the way down to OMAD (one meal a day) with a 2 hour eating window.  Intermittent Fasting (IF) is when you DON’T eat for 24 hours at a stretch.  These fasts may be repeated a few times a week.  Fasting is when there is no food for extended periods, usually 3 to 5 days.  Each of these have some benefits, but with the longer fasting windows resulting in ever increasing risks, some of which are nearly impossible to overcome as the patient gets older.   

As I’ve mentioned, NOT eating for more than 12 hours a day is a good thing.  Most people can easily tolerate 14 hours of not eating – most women don’t benefit from longer daily fasts, though some do.  Many men do well around 16 hours (8 hour eating window).  Once you’re used to it, it becomes pretty easy and there are definite benefits that have been described elsewhere.  

There continues to be some very real questions about what are the specific benefits of daily temporal restriction of caloric intake – this study does answer some of that uncertainty.  

Previous studies have suggested that merely restricting the eating window would end up restricting calories because people had less time to eat, resulting in weight loss.  Sounds silly, but it turns out that that is exactly what seems to be happening.  There was no weight loss associated with TRE versus the exact calorie match of usual eating.  They go on to make some interesting points about confounders (the TRE group went to bed earlier, so less active and thus, less calorie burn) – why stay up if you’re not going to have a snack watching TV?!?

Most people feel better and sleep better if they don’t eat late – stop eating at least 90 minutes before bed, and better yet, 2 hours plus.  These folks got virtually all of their calories before 1 pm – now that’s an early dinner!  The Blue Light special becomes a midnight snack….

Time-Restricted Eating Fails for Weight Loss and Glucose Homeostasis

In the setting of isocaloric eating, time-restricted eating (TRE) did not reduce weight or improve glucose homeostasis relative to a usual eating pattern (UEP), a small randomized controlled trial found.

The results suggested that any effects of TRE on weight observed in prior studies may be due to reductions in caloric intake and not timing, according to Nisa M. Maruthur, MD, MHS, of the Division of General Internal Medicine at the Johns Hopkins School of Medicine in Baltimore, and colleagues.

Published in Annals of Internal Medicine, the 12-week trial randomly assigned 41 adults aged 18-69 years with obesity and prediabetes or diet-controlled diabetes 1:1 as follows: To TRE, involving a 10-hour eating window with 80% of calories consumed before 1 PM, or to UEP, involving a ≤ 16-hour window, with at least 50% of calories consumed after 5 PM. The regimen in each group was based on the OmniHeart unsaturated fat diet and the SPICE study.

"The diet was similar to the DASH [Dietary Approaches to Stop Hypertension] diet for hypertension and maybe a bit higher in unsaturated fat and micronutrients," said study co-author Scott J. Pilla, MD, MHS, an assistant professor of medicine at the Johns Hopkins Bloomberg School of Public Health, Baltimore, in an interview. For each participant, macro- and micronutrient content remained constant throughout the study period, with total calories individually determined at baseline and ranging from 1600 to 3500 kcal/d. "That differs from some TRE studies in which calories were adjusted according to whether participants lost or gained weight," he said. "This was a purely mechanistic study to determine the impact of time of eating alone with no change in calories." 

Although the current findings revealed no weight loss advantage, some evidence suggests that limiting the food consumption window to 4-10 hours naturally reduces energy intake by approximately 200-550 calories per day and can result in a loss of 3%-5% of baseline body weight for 2-12 months. In addition, TRE has been shown to improve metabolic risk factors, such as insulin resistance, blood pressure, and triglyceride concentrations — but not in this study.

The Cohort

The mean age was 59 years, 93% of patients were women, and 93% were Black. The mean body mass index was 36, and the mean baseline weight was 96.2 kg — 95.6 kg in the TRE group and 103.7 kg in the UEP group.

At 12 weeks, weight decreased comparably by 2.3 kg (95% CI, 1.0-3.5) in the TRE group and by 2.6 kg (95% CI, 1.5-3.7) in the UEP group. Change in glycemic measures did not differ between the two groups.

Interestingly, self-reporting questionnaires revealed a slight reduction in physical activity in the TRE group, an effect that requires further study. "We don't know why but anecdotally, some TRE participants said they tended to go to bed earlier," Pilla said. Earlier bedtimes may put an end sooner to the daily eating pattern.

Subanalyses of the data are ongoing and will be published later.

"In the context of several clinical trials that suggest a benefit of TRE, our findings suggest that if or when TRE interventions induce weight loss, it is likely in part due to a reduction in energy intake, and therefore, clinicians can counsel patients that TRE may help them lose weight by decreasing their caloric intake," the authors wrote.

In an accompanying editorial, Krista A. Varady, PhD, and Vanessa M. Oddo, PhD, of the Department of Kinesiology and Nutrition at the University of Illinois Chicago, said the study results have important clinical implications. "Many patients stop following standard-care diets (such as daily calorie restriction) because they become frustrated with having to monitor food intake vigilantly each day," they wrote.

Although TRE is no more effective than other diet interventions for weight reduction, it offers a simplified approach to treat obesity by omitting the need for calorie counting. "TRE bypasses this requirement simply by allowing participants to 'watch the clock' instead of monitoring calories, while still producing weight loss," they wrote.

The straightforward nature of this diet makes it well suited for remote delivery, which can reduce the scheduling and financial barriers associated with inpatient visits, they added. "Moreover, TRE does not require the purchase of expensive food products and allows a person to continue consuming familiar foods, making it a high accessible diet for lower-resource populations."

Gastroenterologists and Obesity

Of late, support has grown for gastroenterologists to become actively involved in obesity treatment — even to "take ownership" of this field.

In a 2023 article in Gut, Michael Camilleri, MD, AGAF, a gastroenterologist at the Mayo Clinic in Rochester, Minnesota, made the case for the natural fit between gastrointestinal (GI) specialists and obesity management. He noted that obesity is a significant risk factor for GI, pancreatic, and liver diseases. It can even affect inflammatory bowel disease.

"Treating obesity starting when patients present in gastroenterology and hepatology clinics has potential to impact serious consequences of obesity such as cardiovascular risks," he wrote.

Gastroenterologists already treat GI conditions with pharmacologic and surgical interventions that can also be used to treat obesity and improve glycemic control. These include pancreatic lipase inhibitors and incretin, bariatric endoscopy and surgery, and combination therapies targeting metabolic problems.

Source: https://www.medscape.com/viewarticle/time-...